Experimental models have often been at the origin of immunological paradigms such as the
M1/M2 dichotomy following macrophage polarization. However, this clear dichotomy in …

Immunometabolism plays a fundamental role in health and diseases and involves multiple
genes and signals. Aconitate decarboxylase 1 (ACOD1; also known as IRG1) is emerging …

Leishmaniasis is a vector-borne neglected tropical disease that affects more than 700,000
people annually. Leishmania parasites cause the disease, and different species trigger a …

Leishmania are protozoan parasites that predominantly reside in myeloid cells within their
mammalian hosts. Monocytes and macrophages play a central role in the pathogenesis of …

Leishmaniasis is a disease complex caused by 20 species of protozoan parasites belonging
to the genus Leishmania. In humans, it has two main clinical forms, visceral leishmaniasis …

The intracellular viral, bacterial, or parasitic pathogens evade the host immune challenges to
propagate and cause fatal diseases. The microbes overpower host immunity at various …

Aberrant macrophage activation during intracellular infection generates immunopathologies
that can cause severe human morbidity. A better understanding of immune subversion …

Visceral Leishmaniasis (VL), a potentially fatal disease is caused by Leishmania donovani
parasites with no vaccine available. Here we produced a dermotropic live attenuated centrin …

For a long time Leishmaniasis had been considered as a neglected tropical disease.
Recently, it has become a priority in public health all over the world for different aspects such …

Leishmaniasis is a complex infectious parasitic disease caused by protozoa of the genus
Leishmania, belonging to a group of neglected tropical diseases. It establishes significant …