The promise of organ and tissue preservation to transform medicine
The ability to replace organs and tissues on demand could save or improve millions of lives
each year globally and create public health benefits on par with curing cancer. Unmet needs …
each year globally and create public health benefits on par with curing cancer. Unmet needs …
Transplanting marginal organs in the era of modern machine perfusion and advanced organ monitoring
T Resch, B Cardini, R Oberhuber… - Frontiers in …, 2020 - frontiersin.org
Organ transplantation is undergoing profound changes. Contraindications for donation have
been revised in order to better meet the organ demand. The use of lower-quality organs and …
been revised in order to better meet the organ demand. The use of lower-quality organs and …
Vitrification and nanowarming enable long-term organ cryopreservation and life-sustaining kidney transplantation in a rat model
Banking cryopreserved organs could transform transplantation into a planned procedure
that more equitably reaches patients regardless of geographical and time constraints …
that more equitably reaches patients regardless of geographical and time constraints …
Supercooling extends preservation time of human livers
The inability to preserve vascular organs beyond several hours contributes to the scarcity of
organs for transplantation,. Standard hypothermic preservation at+ 4° C (refs.,) limits liver …
organs for transplantation,. Standard hypothermic preservation at+ 4° C (refs.,) limits liver …
Biliary bicarbonate, pH, and glucose are suitable biomarkers of biliary viability during ex situ normothermic machine perfusion of human donor livers
APM Matton, Y de Vries, LC Burlage, R van Rijn… - …, 2019 - journals.lww.com
Background. Ex situ normothermic machine perfusion (NMP) can be used to assess viability
of suboptimal donor livers before implantation. Our aim was to assess the diagnostic …
of suboptimal donor livers before implantation. Our aim was to assess the diagnostic …
[HTML][HTML] Preliminary single-center Canadian experience of human normothermic ex vivo liver perfusion: results of a clinical trial
After extensive experimentation, outcomes of a first clinical normothermic machine perfusion
(NMP) liver trial in the United Kingdom demonstrated feasibility and clear safety, with …
(NMP) liver trial in the United Kingdom demonstrated feasibility and clear safety, with …
Partial freezing of rat livers extends preservation time by 5-fold
The limited preservation duration of organs has contributed to the shortage of organs for
transplantation. Recently, a tripling of the storage duration was achieved with supercooling …
transplantation. Recently, a tripling of the storage duration was achieved with supercooling …
Long-term ex situ normothermic perfusion of human split livers for more than 1 week
NS Lau, M Ly, C Dennis, A Jacques… - Nature …, 2023 - nature.com
Current machine perfusion technology permits livers to be preserved ex situ for short periods
to assess viability prior to transplant. Long-term normothermic perfusion of livers is an …
to assess viability prior to transplant. Long-term normothermic perfusion of livers is an …
Supercooling enables long-term transplantation survival following 4 days of liver preservation
TA Berendsen, BG Bruinsma, CF Puts, N Saeidi… - Nature medicine, 2014 - nature.com
The realization of long-term human organ preservation will have groundbreaking effects on
the current practice of transplantation. Herein we present a new technique based on …
the current practice of transplantation. Herein we present a new technique based on …
[HTML][HTML] Machine perfusion of donor livers for transplantation: a proposal for standardized nomenclature and reporting guidelines
SA Karangwa, P Dutkowski, P Fontes, PJ Friend… - American journal of …, 2016 - Elsevier
With increasing demand for donor organs for transplantation, machine perfusion (MP)
promises to be a beneficial alternative preservation method for donor livers, particularly …
promises to be a beneficial alternative preservation method for donor livers, particularly …