The ability to replace organs and tissues on demand could save or improve millions of lives
each year globally and create public health benefits on par with curing cancer. Unmet needs …

Organ transplantation is undergoing profound changes. Contraindications for donation have
been revised in order to better meet the organ demand. The use of lower-quality organs and …

Banking cryopreserved organs could transform transplantation into a planned procedure
that more equitably reaches patients regardless of geographical and time constraints …

The inability to preserve vascular organs beyond several hours contributes to the scarcity of
organs for transplantation,. Standard hypothermic preservation at+ 4° C (refs.,) limits liver …

Background. Ex situ normothermic machine perfusion (NMP) can be used to assess viability
of suboptimal donor livers before implantation. Our aim was to assess the diagnostic …

After extensive experimentation, outcomes of a first clinical normothermic machine perfusion
(NMP) liver trial in the United Kingdom demonstrated feasibility and clear safety, with …

The limited preservation duration of organs has contributed to the shortage of organs for
transplantation. Recently, a tripling of the storage duration was achieved with supercooling …

Current machine perfusion technology permits livers to be preserved ex situ for short periods
to assess viability prior to transplant. Long-term normothermic perfusion of livers is an …

The realization of long-term human organ preservation will have groundbreaking effects on
the current practice of transplantation. Herein we present a new technique based on …

With increasing demand for donor organs for transplantation, machine perfusion (MP)
promises to be a beneficial alternative preservation method for donor livers, particularly …