Oxidative stress and inflammation in osteoporosis: molecular mechanisms involved and the relationship with microRNAs

T Iantomasi, C Romagnoli, G Palmini, S Donati… - International journal of …, 2023 - mdpi.com
Osteoporosis is characterized by the alteration of bone homeostasis due to an imbalance
between osteoclastic bone resorption and osteoblastic bone formation. Estrogen deficiency …

Topography-mediated immunomodulation in osseointegration; Ally or Enemy

S Shirazi, S Ravindran, LF Cooper - Biomaterials, 2022 - Elsevier
Osteoimmunology is at full display during endosseous implant osseointegration. Bone
formation, maintenance and resorption at the implant surface is a result of bidirectional and …

[HTML][HTML] M2 macrophage-derived exosomes promote diabetic fracture healing by acting as an immunomodulator

Y Wang, Q Lin, H Zhang, S Wang, J Cui, Y Hu, J Liu… - Bioactive materials, 2023 - Elsevier
Diabetes mellitus is a chronically inflamed disease that predisposes to delayed fracture
healing. Macrophages play a key role in the process of fracture healing by undergoing …

Systemic immune-inflammation index and bone mineral density in postmenopausal women: A cross-sectional study of the national health and nutrition examination …

Y Tang, B Peng, J Liu, Z Liu, Y Xia, B Geng - Frontiers in immunology, 2022 - frontiersin.org
Background This study aimed to investigate the association between the systemic immune-
inflammation index (SII) and bone mineral density (BMD) and to determine the association …

Urolithin A suppresses RANKL-induced osteoclastogenesis and postmenopausal osteoporosis by, suppresses inflammation and downstream NF-κB activated …

H Tao, W Li, W Zhang, C Yang, C Zhang, X Liang… - Pharmacological …, 2021 - Elsevier
Osteoporosis (OP) is characterized by decreased trabecular bone volume and
microarchitectural deterioration in the medullary cavity. Urolithin A (UA) is a biologically …

Advances in materials-based therapeutic strategies against osteoporosis

C Lei, J Song, S Li, Y Zhu, M Liu, M Wan, Z Mu, FR Tay… - Biomaterials, 2023 - Elsevier
Osteoporosis is caused by the disruption in homeostasis between bone formation and bone
resorption. Conventional management of osteoporosis involves systematic drug …

Obesity and bone health: a complex relationship

A Piñar-Gutierrez, C García-Fontana… - International journal of …, 2022 - mdpi.com
Recent scientific evidence has shown an increased risk of fractures in patients with obesity,
especially in those with a higher visceral adipose tissue content. This contradicts the old …

Structural and metabolic changes in bone

A Wawrzyniak, K Balawender - Animals, 2022 - mdpi.com
Simple Summary Bone is an extremely metabolically active tissue that is regenerated and
repaired over its lifetime by bone remodeling. Most bone diseases are caused by abnormal …

Exercise for osteoporosis: a literature review of pathology and mechanism

L Zhang, YL Zheng, R Wang, XQ Wang… - Frontiers in …, 2022 - frontiersin.org
Osteoporosis (OP) is a disease that weakens bones and has a high morbidity rate
worldwide, which is prevalent among the elderly, particularly, women of postmenopausal …

Immunoporosis: Role of immune system in the pathophysiology of different types of osteoporosis

W Zhang, R Gao, X Rong, S Zhu, Y Cui… - Frontiers in …, 2022 - frontiersin.org
Osteoporosis is a skeletal system disease characterized by low bone mass and altered bone
microarchitecture, with an increased risk of fractures. Classical theories hold that …