Stem cell factor (SCF) is a dimeric molecule that exerts its biological functions by binding to
and activating the receptor tyrosine kinase c-Kit. Activation of c-Kit leads to its …

c-Kit, a receptor tyrosine kinase, is involved in intracellular signaling, and the mutated form
of c-Kit plays a crucial role in occurrence of some cancers. The function of c-Kit has led to the …

A number of different intracellular signaling pathways have been shown to be activated by
receptor tyrosine kinases. These activation events include the phosphoinositide 3-kinase, 70 …

Abstract c-kit is a classical proto-oncogene that encodes a receptor tyrosine kinase (RTK)
that responds to stem cell factor (SCF). C-KIT signaling is a critical regulator of cell …

Background Soft-tissue tumours are derived from mesenchymal cells such as fibroblasts,
muscle cells, or adipocytes, but for many such tumours the histogenesis is controversial. We …

The receptor tyrosine kinase c-Kit is expressed in hematopoietic stem and progenitor cells
and in several non-hematopoietic tissues. In the hematopoietic system, c-Kit is critical for …

Translocation of conventional protein kinases C (PKCs) to the plasma membrane leads to
their specific association with transmembrane-4 superfamily (TM4SF; tetraspanin) proteins …

c-Kit is a receptor tyrosine kinase that binds stem cell factor (SCF). Structurally, c-Kit contains
five immunoglobulin-like domains extracellularly and a catalytic domain divided into two …

The c-kit-encoded receptor protein tyrosine kinase for stem cell factor (Kit/SCF-R) is
essential for the development of cells within the hematopoietic, melanogenic and …

Kit is a receptor tyrosine kinase (RTK) that binds stem cell factor. This receptor ligand
combination is important for normal hematopoiesis, as well as pigmentation, gut function …