Do cryptic reservoirs threaten gambiense-sleeping sickness elimination?
P Büscher, JM Bart, M Boelaert, B Bucheton… - Trends in …, 2018 - cell.com
Trypanosoma brucei gambiense causes human African trypanosomiasis (HAT). Between
1990 and 2015, almost 440000 cases were reported. Large-scale screening of populations …
1990 and 2015, almost 440000 cases were reported. Large-scale screening of populations …
[HTML][HTML] Immunology and immunopathology of African trypanosomiasis
P Vincendeau, B Bouteille - Anais da Academia Brasileira de …, 2006 - SciELO Brasil
Major modifications of immune system have been observed in African trypanosomiasis.
These immune reactions do not lead to protection and are also involved in …
These immune reactions do not lead to protection and are also involved in …
Untreated Human Infections by Trypanosoma brucei gambiense Are Not 100% Fatal
The final outcome of infection by Trypanosoma brucei gambiense, the main agent of
sleeping sickness, has always been considered as invariably fatal. While scarce and old …
sleeping sickness, has always been considered as invariably fatal. While scarce and old …
Human host determinants influencing the outcome of Trypanosoma brucei gambiense infections
B Bucheton, A MacLeod, V Jamonneau - Parasite Immunology, 2011 - Wiley Online Library
Since first identified, human African trypanosomiasis (HAT) or sleeping sickness has been
described as invariably fatal. Increasing data however argue that infection by Trypanosoma …
described as invariably fatal. Increasing data however argue that infection by Trypanosoma …
Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P
T Bosschaerts, M Guilliams, W Noel… - The Journal of …, 2008 - journals.aai.org
Uncontrolled inflammation is a major cause of tissue injury/pathogenicity often resulting in
death of a host infected with African trypanosomes. Thus, comparing the immune response …
death of a host infected with African trypanosomes. Thus, comparing the immune response …
Tolerance to trypanosomatids: a threat, or a key for disease elimination?
D Berthier, SF Brenière, R Bras-Gonçalves… - Trends in …, 2016 - cell.com
So far, research on trypanosomatid infections has been driven by 'disease by
disease'approaches, leading to different concepts and control strategies. It is, however …
disease'approaches, leading to different concepts and control strategies. It is, however …
When cats' ways of life interact with their viruses: A study in 15 natural populations of owned and unowned cats (Felis silvestris catus)
E Hellard, D Fouchet, H Santin-Janin, B Tarin… - Preventive veterinary …, 2011 - Elsevier
In natural populations, virus circulation is influenced by host behavior and physiological
characteristics. Cat populations exhibit a great variability in social and spatial structure, the …
characteristics. Cat populations exhibit a great variability in social and spatial structure, the …
A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome
Trypanosoma brucei is the causative agent of African sleeping sickness in humans and one
of several pathogens that cause the related veterinary disease Nagana. A complex co …
of several pathogens that cause the related veterinary disease Nagana. A complex co …
Host genetics in African trypanosomiasis
D Courtin, D Berthier, S Thevenon, GK Dayo… - Infection, Genetics and …, 2008 - Elsevier
In Africa, the protozoan parasite of the genus Trypanosoma causes animal (AAT) and
human African trypanosomiasis (HAT). These diseases are responsible for considerable …
human African trypanosomiasis (HAT). These diseases are responsible for considerable …
A spectrum of disease in human African trypanosomiasis: the host and parasite genetics of virulence
JM Sternberg, L MacLean - Parasitology, 2010 - cambridge.org
For over 50 years it has been known that there are considerable differences in the severity
and rate of progression of both Trypanosoma brucei rhodesiense and T. b. gambiense …
and rate of progression of both Trypanosoma brucei rhodesiense and T. b. gambiense …