Do cryptic reservoirs threaten gambiense-sleeping sickness elimination?

P Büscher, JM Bart, M Boelaert, B Bucheton… - Trends in …, 2018 - cell.com
Trypanosoma brucei gambiense causes human African trypanosomiasis (HAT). Between
1990 and 2015, almost 440000 cases were reported. Large-scale screening of populations …

[HTML][HTML] Immunology and immunopathology of African trypanosomiasis

P Vincendeau, B Bouteille - Anais da Academia Brasileira de …, 2006 - SciELO Brasil
Major modifications of immune system have been observed in African trypanosomiasis.
These immune reactions do not lead to protection and are also involved in …

Untreated Human Infections by Trypanosoma brucei gambiense Are Not 100% Fatal

V Jamonneau, H Ilboudo, J Kaboré… - PLoS neglected …, 2012 - journals.plos.org
The final outcome of infection by Trypanosoma brucei gambiense, the main agent of
sleeping sickness, has always been considered as invariably fatal. While scarce and old …

Human host determinants influencing the outcome of Trypanosoma brucei gambiense infections

B Bucheton, A MacLeod, V Jamonneau - Parasite Immunology, 2011 - Wiley Online Library
Since first identified, human African trypanosomiasis (HAT) or sleeping sickness has been
described as invariably fatal. Increasing data however argue that infection by Trypanosoma …

Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P

T Bosschaerts, M Guilliams, W Noel… - The Journal of …, 2008 - journals.aai.org
Uncontrolled inflammation is a major cause of tissue injury/pathogenicity often resulting in
death of a host infected with African trypanosomes. Thus, comparing the immune response …

Tolerance to trypanosomatids: a threat, or a key for disease elimination?

D Berthier, SF Brenière, R Bras-Gonçalves… - Trends in …, 2016 - cell.com
So far, research on trypanosomatid infections has been driven by 'disease by
disease'approaches, leading to different concepts and control strategies. It is, however …

When cats' ways of life interact with their viruses: A study in 15 natural populations of owned and unowned cats (Felis silvestris catus)

E Hellard, D Fouchet, H Santin-Janin, B Tarin… - Preventive veterinary …, 2011 - Elsevier
In natural populations, virus circulation is influenced by host behavior and physiological
characteristics. Cat populations exhibit a great variability in social and spatial structure, the …

A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome

P Capewell, A Cooper, C Clucas, W Weir, A Macleod - Parasitology, 2015 - cambridge.org
Trypanosoma brucei is the causative agent of African sleeping sickness in humans and one
of several pathogens that cause the related veterinary disease Nagana. A complex co …

Host genetics in African trypanosomiasis

D Courtin, D Berthier, S Thevenon, GK Dayo… - Infection, Genetics and …, 2008 - Elsevier
In Africa, the protozoan parasite of the genus Trypanosoma causes animal (AAT) and
human African trypanosomiasis (HAT). These diseases are responsible for considerable …

A spectrum of disease in human African trypanosomiasis: the host and parasite genetics of virulence

JM Sternberg, L MacLean - Parasitology, 2010 - cambridge.org
For over 50 years it has been known that there are considerable differences in the severity
and rate of progression of both Trypanosoma brucei rhodesiense and T. b. gambiense …