Interleukin-33 (IL-33) plays multiple roles in tissue homeostasis, prevention of parasitic
infection, and induction of allergic inflammation. Especially, IL-33-ST2 (IL-1RL1) axis has …

The immune system regulates itself to establish an appropriate immune response to
potentially harmful pathogens while tolerating harmless environmental antigens and self …

Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous
inflammatory airway disease. The epithelial-derived IL-33 and its receptor ST2 have been …

Regulatory T (Treg) cells accumulate into tumors, hindering the success of cancer
immunotherapy. Yet, therapeutic targeting of Treg cells shows limited efficacy or leads to …

Abstract Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines that play a central
role in the regulation of immune responses. Its release from epithelial and endothelial cells …

Rheumatoid arthritis (RA) is a widespread chronic autoimmune disorder affecting the joints,
causing irreversible cartilage, synovium, and bone degradation. During the course of the …

Abstract Alzheimer's disease (AD), an extremely common neurodegenerative disorder of the
older generation, is one of the leading causes of death globally. Besides the conventional …

The pleiotropic alarmin interleukin-33 (IL-33) drives type 1, type 2 and regulatory T-cell
responses via its receptor ST2. Subset-specific differences in ST2 expression intensity and …

Interleukin-33 (IL-33), considered as an alarmin released upon tissue stress or damage, is a
member of the IL-1 family and binds the ST2 receptor. First described as a potent initiator of …

The intestinal tract is the largest immune organ in the human body, comprising a complex
network of immune cells and epithelial cells that perform a variety of functions such as …