Pediatric neuro-oncology has undergone an exciting and dramatic transformation during the
past 5 years. This article summarizes data from collaborative group and institutional trials …

The mammalian cerebellum is located in the posterior cranial fossa and is critical for motor
coordination and non-motor functions including cognitive and emotional processes. The …

Medulloblastoma, a malignant childhood cerebellar tumour, segregates molecularly into
biologically distinct subgroups, suggesting that a personalized approach to therapy would …

Medulloblastoma is a malignant childhood cerebellar tumour type that comprises distinct
molecular subgroups. Whereas genomic characteristics of these subgroups are well …

Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-
specific biomarkers. Because cell-free DNA from brain and spinal cord tumors cannot …

The childhood brain tumor, medulloblastoma, includes four subtypes with very different
prognoses. Here, we show that paracrine signals driven by mutant β-catenin in WNT …

Background Young children with medulloblastoma have a poor overall survival compared
with older children, due to use of radiation-sparing therapy in young children. Radiotherapy …

Abstract Medulloblastoma accounts for 15–20% of childhood nervous system tumours. The
risk of dying was reduced by 30% in the last twenty years. Patients are divided in risk strata …

The permanent defects in bone growth observed in preclinical studies of hedgehog (Hh)
pathway inhibitors were not substantiated in early phase clinical studies of vismodegib in …

Central nervous system (CNS) tumors are the most common solid tumor in pediatrics,
accounting for approximately 25% of all childhood cancers, and the second most common …