Pediatric brain tumors including medulloblastoma and atypical teratoid/rhabdoid tumor are
associated with significant mortality and treatment-associated morbidity. While …

Abstract Uncontrolled Hedgehog (Hh) signaling is the cause of several malignancies,
including the pediatric cancer medulloblastoma, a neuroectodermal tumor affecting the …

Background Treatment of pediatric medulloblastoma is associated with known
neurocognitive deficits that we hypothesize are caused by microstructural damage to frontal …

OBJECTIVE Medulloblastoma is a type of malignant tumor arising in the cerebellum. The
clinical importance of programmed cell death 1 ligand–1 (PD-L1) expression in …

Aberrant activation and interactions of hedgehog (HH) and PI3K/AKT/mTOR signaling
pathways are frequently associated with high-risk medulloblastoma (MB). Thus, combined …

Medulloblastoma, an embryonal tumor of the cerebellum/fourth ventricle, is one of the most
frequent malignant brain tumors in children. Although genetic variants are increasingly used …

Abstract We evaluated the American College of Surgeon's National Cancer Data Base
(NCDB) to describe current hospital-based epidemiologic frequency, survival, and patterns …

Aberrant Hedgehog signaling and excessive activation of the Gli family of transcriptional
activators are key drivers of medulloblastoma (MB), the most common human pediatric brain …

Great progress has been made in many areas of pediatric oncology. However, tumors of the
central nervous system (CNS) remain a significant challenge. A recent explosion of data has …

Abstract SHH‐activated medulloblastomas (SHH‐MB) account for 25–30% of all
medulloblastomas (MB) and occur with a bimodal age distribution, encompassing many …