Adenosine A2A receptor antagonists KF17837 and KW-6002 potentiate rotation induced by dopaminergic drugs in hemi-Parkinsonian rats
K Koga, M Kurokawa, M Ochi, J Nakamura… - European journal of …, 2000 - Elsevier
The effects of novel adenosine A2A receptor antagonists KF17837 ((E)-1, 3-dipropyl-8-(3, 4-
dimethoxystyryl)-7-methyl-3, 7-dihydro-1H-purine-2, 6-dione) and KW-6002 ((E)-1, 3-diethyl …
dimethoxystyryl)-7-methyl-3, 7-dihydro-1H-purine-2, 6-dione) and KW-6002 ((E)-1, 3-diethyl …
Activation of adenosine A2A and dopamine D1 receptors stimulates cyclic AMP-dependent phosphorylation of DARPP-32 in distinct populations of striatal projection …
P Svenningsson, M Lindskog, F Rognoni, BB Fredholm… - Neuroscience, 1998 - Elsevier
In the striatum, adenosine A2A and dopamine D1 receptors are segregated in striatopallidal
and striatonigral projection neurons, respectively. In this study, we have examined the …
and striatonigral projection neurons, respectively. In this study, we have examined the …
The pathophysiology of chorea/ballism and parkinsonism
RL Albin - Parkinsonism & related disorders, 1995 - Elsevier
Recent neurobiological investigations indicate the presence of three principles of basal
ganglia organization—the existence of segregated striatal output pathways, the differential …
ganglia organization—the existence of segregated striatal output pathways, the differential …
A dual role of adenosine A2A receptors in 3-nitropropionic acid-induced striatal lesions: implications for the neuroprotective potential of A2A antagonists
D Blum, MC Galas, A Pintor, E Brouillet… - Journal of …, 2003 - Soc Neuroscience
Reduction of A2A receptor expression is one of the earliest events occurring in both
Huntington's disease (HD) patients and mice overexpressing the N-terminal part of mutated …
Huntington's disease (HD) patients and mice overexpressing the N-terminal part of mutated …
An evaluation of istradefylline treatment on Parkinsonian motor and cognitive deficits in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-treated macaque …
WKD Ko, SM Camus, Q Li, J Yang, S McGuire… - …, 2016 - Elsevier
Abstract Istradefylline (KW-6002), an adenosine A2A receptor antagonist, is used adjunct
with optimal doses of L-3, 4-dihydroxyphenylalanine (l-DOPA) to extend on-time in …
with optimal doses of L-3, 4-dihydroxyphenylalanine (l-DOPA) to extend on-time in …
Novel investigational adenosine A2A receptor antagonists for Parkinson's disease
A Pinna - Expert opinion on investigational drugs, 2009 - Taylor & Francis
The development of non-dopaminergic therapies for Parkinson's disease (PD) has attracted
much interest in recent years. Among new classes of drugs, adenosine A2A antagonists …
much interest in recent years. Among new classes of drugs, adenosine A2A antagonists …
Blockade of A2a Adenosine Receptors Positively Modulates Turning Behaviour and c‐Fos Expression Induced by D1 Agonists in Dopamine‐denervated Rats
A Pinna, G Di Chiara, J Wardas… - European Journal of …, 1996 - Wiley Online Library
In rats with unilateral 6‐hydroxydopamine lesions of the dopaminergic nigrostriatal pathway,
administration of the A2a adenosine antagonist SCH 58261 alone did not induce any motor …
administration of the A2a adenosine antagonist SCH 58261 alone did not induce any motor …
Cannabinoid action depends on phosphorylation of dopamine-and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neurons
M Andersson, A Usiello, A Borgkvist… - Journal of …, 2005 - Soc Neuroscience
Herbal cannabis, smoked in the form of marihuana or hashish, is the most common illicit
drug consumed in the Western world. In the brain, cannabinoids interact with neuronal CB1 …
drug consumed in the Western world. In the brain, cannabinoids interact with neuronal CB1 …
Extrasynaptic neurotransmission in the modulation of brain function. Focus on the striatal neuronal–glial networks
K Fuxe, DO Borroto-Escuela… - Frontiers in …, 2012 - frontiersin.org
Extrasynaptic neurotransmission is an important short distance form of volume transmission
(VT) and describes the extracellular diffusion of transmitters and modulators after synaptic …
(VT) and describes the extracellular diffusion of transmitters and modulators after synaptic …
Homeostatic plasticity of striatal neurons intrinsic excitability following dopamine depletion
K Azdad, M Chàvez, PD Bischop, P Wetzelaer… - PloS one, 2009 - journals.plos.org
The striatum is the major input structure of basal ganglia and is involved in adaptive control
of behaviour through the selection of relevant informations. Dopaminergic neurons that …
of behaviour through the selection of relevant informations. Dopaminergic neurons that …