What Is the Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease?
Huntington's disease (HD) is a devastating hereditary neurodegenerative disorder caused
by a CAG mutation within the IT15 gene encoding huntingtin protein. Even though mutant …
by a CAG mutation within the IT15 gene encoding huntingtin protein. Even though mutant …
Efficacy of istradefylline for gait disorders with freezing of gait in Parkinson's disease: a single-arm, open-label, prospective, multicenter study
M Iijima, S Orimo, H Terashi, M Suzuki… - Expert Opinion on …, 2019 - Taylor & Francis
Background: Gait disorders are common in Parkinson's disease patients who respond
poorly to dopaminergic treatment. Blockade of adenosine A2A receptors is expected to …
poorly to dopaminergic treatment. Blockade of adenosine A2A receptors is expected to …
Electrophysiological and behavioural evidence for an antagonistic modulatory role of adenosine A2A receptors in dopamine D2 receptor regulation in the rat …
I Strömberg, P Popoli, CE Müller… - European Journal of …, 2000 - Wiley Online Library
It has been shown that striatal adenosine A2A receptors can antagonistically interact with
dopamine D2 receptors at the membrane level leading to a decrease in the affinity and …
dopamine D2 receptors at the membrane level leading to a decrease in the affinity and …
Adenosine A2a receptor mRNA is expressed by enkephalin cells but not by somatostatin cells in rat striatum: a co-expression study
SJ Augood, PC Emson - Molecular brain research, 1994 - Elsevier
The cellular co-expression of adenosine A 2a receptor mRNA and preproenkephalin A (PPE
A) mRNA and A 2a receptor mRNA and prosomatostatin (pSRIF) mRNA in rat striatum was …
A) mRNA and A 2a receptor mRNA and prosomatostatin (pSRIF) mRNA in rat striatum was …
Opposite tonic modulation of dopamine and adenosine on c-fos gene expression in striatopallidal neurons
P Svenningsson, L Fourreau, B Bloch, BB Fredholm… - Neuroscience, 1999 - Elsevier
The impulse flow-dependent dopamine release in the striatum was acutely blocked by
unilateral lesion of the medial forebrain bundle with 6-hydroxydopamine. Within 45min this …
unilateral lesion of the medial forebrain bundle with 6-hydroxydopamine. Within 45min this …
Cellular distribution of adenosine A2A receptor mrna in the primate striatum
P Svenningsson, C Le Moine, I Aubert… - Journal of …, 1998 - Wiley Online Library
The cellular expression of adenosine A2A receptor mRNA in the adult monkey and human
striatum was examined by using single and double in situ hybridization with ribonucleotide …
striatum was examined by using single and double in situ hybridization with ribonucleotide …
[HTML][HTML] Homeostatic plasticity of striatal neurons intrinsic excitability following dopamine depletion
K Azdad, M Chàvez, PD Bischop, P Wetzelaer… - PloS one, 2009 - journals.plos.org
The striatum is the major input structure of basal ganglia and is involved in adaptive control
of behaviour through the selection of relevant informations. Dopaminergic neurons that …
of behaviour through the selection of relevant informations. Dopaminergic neurons that …
Effects of chronic administration of adenosine A1 receptor agonist and antagonist on spatial learning and memory
DKJE Von Lubitz, IA Paul, RT Bartus… - European journal of …, 1993 - Elsevier
Spatial memory acquisition in Morris water maze was tested in C57BL/6 mice. Animals were
injected once daily with different doses of either N 6-cyclopentyladenosine (CPA) or 8 …
injected once daily with different doses of either N 6-cyclopentyladenosine (CPA) or 8 …
Alterations in preproenkephalin and adenosine‐2a receptor mRNA, but not preprotachykinin mRNA correlate with occurrence of dyskinesia in normal monkeys …
BY Zeng, RKB Pearce, GM MacKenzie… - European Journal of …, 2000 - Wiley Online Library
Chronic treatment with l‐DOPA induces dyskinesia in patients with Parkinson's disease (PD)
and 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine (MPTP)‐treated monkeys, but is not …
and 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine (MPTP)‐treated monkeys, but is not …
[HTML][HTML] Targeting neuronal populations of the striatum
PF Durieux, SN Schiffmann… - Frontiers in neuroanatomy, 2011 - frontiersin.org
The striatum is critically involved in motor and motivational functions. The dorsal striatum,
caudate–putamen, is primarily implicated in motor control and the learning of habits and …
caudate–putamen, is primarily implicated in motor control and the learning of habits and …