Intact, coordinated, and precisely regulated cerebrovascular responses are required for the
maintenance of cerebral metabolic homeostasis, adequate perfusion, oxygen delivery, and …

Quantitative measurements of brain perfusion are influenced by perfusion-modifiers.
Standardization of measurement conditions and correction for important modifiers is …

Current methods of forcing end‐tidal PCO2 (PETCO2) and PO2 (PETO2) rely on breath‐by‐
breath adjustment of inspired gas concentrations using feedback loop algorithms. Such …

Clinical transcranial Doppler assessment of cerebral vasomotor reactivity (CVMR) uses
linear regression of cerebral blood flow velocity (CBFV) vs. end-tidal CO2 (PetCO2) under …

An important determinant of [H+] in the environment of the central chemoreceptors is
cerebral blood flow. Accordingly we hypothesized that a reduction of brain perfusion or a …

Rationale: Cerebrovascular reactivity to CO2 provides an important counterregulatory
mechanism that serves to minimize the change in H+ at the central chemoreceptor, thereby …

Breathing responds to changes in CO 2 and O 2 detected by respiratory chemoreceptors. In
this paper I examine the methodologies for a quantitative assessment of the respiratory …

After defining the current approach to measuring the hypoxic ventilatory response this paper
explains why this method is not appropriate for comparisons between individuals or …

Evidence for shear stress as a regulator of carotid artery dilation in response to increased
arterial CO2 was recently demonstrated in humans during sustained elevations in CO2 …

Indomethacin (INDO), a reversible cyclooxygenase inhibitor, is a useful tool for assessing
the role of cerebrovascular reactivity on ventilatory control. Despite this, the effect of INDO on …