The use and abuse of growth hormone in sports
GH is banned by the World Anti-Doping Agency as a performance-enhancing anabolic
agent. Doping with GH likely began in the early 1980s and became more prevalent with the …
agent. Doping with GH likely began in the early 1980s and became more prevalent with the …
Metabolic actions of growth hormone in man
KEN KYHO, AJ O'SULLIVAN, DM HOFFMAN - Endocrine Journal, 1996 - jstage.jst.go.jp
GH continues to be produced after the cessation of childhood growth and is the most
abundant pituitary hormone in the adult pituitary. There is strong evidence that GH continues …
abundant pituitary hormone in the adult pituitary. There is strong evidence that GH continues …
Diagnosis of growth-hormone deficiency in adults
DM Hoffman, AJ O'Sullivan, KKY Ho, RC Baxter - The Lancet, 1994 - Elsevier
There is no consensus as to the most appropriate method of diagnosing growth-hormone
(GH) deficiency in adults. We have evaluated the relative diagnostic merits of measuring …
(GH) deficiency in adults. We have evaluated the relative diagnostic merits of measuring …
Insulin regulation of human hepatic growth hormone receptors: divergent effects on biosynthesis and surface translocation
KC Leung, N Doyle, M Ballesteros… - The Journal of …, 2000 - academic.oup.com
Insulin modulates the biological actions of GH, but little is known about its effect on human
hepatic GH receptors (GHRs). Using the human hepatoma cell line HuH7 as a model, we …
hepatic GH receptors (GHRs). Using the human hepatoma cell line HuH7 as a model, we …
Growth hormone treatment of adults withgrowth hormone deficiency: results of a 13‐month placebo controlled cross‐over study
HM Whitehead, C Boreham, EM Mcllrath… - Clinical …, 1992 - Wiley Online Library
Summary objective We aimed to study the effect of biosynthetlc growth hormone (GH)
replacement In growth hormone deficient adults. design We performed a double‐blind …
replacement In growth hormone deficient adults. design We performed a double‐blind …
Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2
KC Leung, N Doyle, M Ballesteros… - Proceedings of the …, 2003 - National Acad Sciences
Oral estrogen administration attenuates the metabolic action of growth hormone (GH) in
humans. To investigate the mechanism involved, we studied the effects of estrogen on GH …
humans. To investigate the mechanism involved, we studied the effects of estrogen on GH …
Binding and functional studies with the growth hormone receptor antagonist, B2036-PEG (pegvisomant), reveal effects of pegylation and evidence that it binds to a …
RJM Ross, KC Leung, M Maamra… - The Journal of …, 2001 - academic.oup.com
GH actions are dependent on receptor dimerization. The GH receptor antagonist, B2036-
PEG, has been developed for treating acromegaly. B2036 has mutations in site 1 to …
PEG, has been developed for treating acromegaly. B2036 has mutations in site 1 to …
Effects of long-term elevated serum levels of growth hormone on life expectancy of mice: lessons from transgenic animal models
E Wolf, E Kahnt, J Ehrlein, W Hermanns, G Brem… - Mechanisms of ageing …, 1993 - Elsevier
In this study, we characterize transgenic mice carrying fusion genes, in which the genes
coding for human (h) or bovine (b) growth hormone (GH) have been put under the …
coding for human (h) or bovine (b) growth hormone (GH) have been put under the …
A bottom-up whole-body physiologically based pharmacokinetic model to mechanistically predict tissue distribution and the rate of subcutaneous absorption of …
KL Gill, I Gardner, L Li, M Jamei - The AAPS journal, 2016 - Springer
The ability to predict subcutaneous (SC) absorption rate and tissue distribution of
therapeutic proteins (TPs) using a bottom-up approach is highly desirable early in the drug …
therapeutic proteins (TPs) using a bottom-up approach is highly desirable early in the drug …
The antinatriuretic action of biosynthetic human growth hormone in man involves activation of the renin-angiotensin system
KY Ho, AJ Weissberger - Metabolism, 1990 - Elsevier
Previous studies using human pituitary extracts have not resolved whether the sodium
retaining effects of human growth hormone (hGH) are mediated in part by increased …
retaining effects of human growth hormone (hGH) are mediated in part by increased …