The role of androgen receptor (AR) activation and expression is well understood in prostate
cancer. In breast cancer, expression and activation of AR is increasingly recognized for its …

Simple Summary The CREB-binding protein (CBP) and p300 are paralogous lysine
acetyltransferases that serve as critical co-activators for transcription factors involved in …

Huggins and Hodges demonstrated the therapeutic effect of gonadal testosterone
deprivation in the 1940s and therefore firmly established the concept that prostate cancer is …

Prostate cancer (PCa) is the most common cancer in men. The androgen receptor (AR) has
a pivotal role in the pathogenesis and progression of PCa. Many therapies targeting AR …

The androgen receptor (AR) plays a predominant role in prostate cancer (PCa) pathology. It
consists of an N-terminal domain (NTD), a DNA-binding domain (DBD), a hinge region (HR) …

Androgens, the predominant male sex hormones, drive the development and maintenance
of male characteristics by binding to androgen receptor (AR). As androgens are systemically …

Gonadal steroidogenesis is pivotal to synchronize various reproductive stages including
sexual development, growth and maturation. In all vertebrates including teleost …

Traditional endocrine therapy for prostate cancer (PCa) has been directed at suppression of
the androgen receptor (AR) signaling axis since Huggins et al. discovered that …

Acknowledgements: The authors wish to thank Sima Rabinowitz, SR for editorial assistance.
The authors wish to acknowledge funding support from the Deane Prostate Health, ISMMS …

Many therapeutic options are now available for men with metastatic castration-resistant
prostate cancer (mCRPC), including next-generation androgen receptor axis-targeted …