Chromosomal translocations involving antigen receptor loci are common in lymphoid
malignancies. Translocations require DNA double-strand breaks (DSBs) at two …

Neonatal CD4+ and CD8+ T cells have historically been characterized as immature or
defective. However, recent studies prompt a reinterpretation of the functions of neonatal T …

The specificities of lymphocytes for antigen are generated by a quasi-random process of
gene rearrangement that often results in non-functional or autoreactive antigen receptors …

Three Pol X family members have been linked to nonhomologous end joining (NHEJ) in
mammals. Template-independent TdT promotes diversity during NHEJ-dependent repair of …

Mammalian DNA polymerase μ (pol μ) is related to terminal deoxynucleotidyl transferase,
but its biological role is not yet clear. We show here that after exposure of cells to ionizing …

A new gene (POLL) encoding a novel DNA polymerase (Pol λ) has been identified at mouse
chromosome 19. Murine Pol λ, consisting of 573 amino acid residues, has a 32% identity to …

T cell maturation requires the rearrangement of clonotypic T cell receptors (TCR) capable of
interacting with major histocompatibility complex (MHC) ligands to initiate positive and …

In mice, the absence of terminal deoxynucleotidyl transferase (Tdt) expression during fetal
and neonatal life provides a window in development where clones of lymphocytes are …

▪ Abstract Cells have high-fidelity polymerases whose task is to accurately replicate the
genome, and low-fidelity polymerases with specialized functions. Although some of these …

The mammalian family X DNA polymerases (DNA polymerases β, λ, μ, and TdT) contribute
to base excision repair and double-strand break repair by virtue of their ability to fill short …