In the adult mammalian brain, more than 250 protein kinases are expressed, but only a few
of these kinases are currently known to enable learning and memory. Based on this …

Learning and memory require the formation of new neural networks in the brain. A key
mechanism underlying this process is synaptic plasticity at excitatory synapses, which …

The main characteristic of alcohol use disorder is the consumption of large quantities of
alcohol despite the negative consequences. The transition from the moderate use of alcohol …

The MAPK pathway is a prominent intracellular signaling pathway regulating various
intracellular functions. Components of this pathway are mutated in a related collection of …

Background Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by
mutations in the transcriptional regulator MeCP2. Much of our understanding of MeCP2 …

The N-methyl-D-aspartate receptors (NMDARs) are part of a large multiprotein complex at
the glutamatergic synapse. The assembly of NMDARs with synaptic proteins offers a means …

Prion diseases typically have long pre-clinical incubation periods during which time the
infectious prion particle and infectivity steadily propagate in the brain. Abnormal neuritic …

The firing of mesolimbic dopamine neurons is important for drug-induced reinforcement,
although underlying genetic factors remain poorly understood. In a recent genome-wide …

Glutamate N-methyl-D-aspartate receptor (NMDAR) is critical for promoting physiological
synaptic plasticity and neuronal viability. As a major subpopulation of the NMDAR, the …

The highly conserved mitogen-activated protein kinase/extracellular signal-regulated kinase
(MAPK/ERK) signaling cascade is involved in several intracellular processes ranging from …