Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Fibrosis is a process characterized by an excessive accumulation of the extracellular matrix
as a response to different types of tissue injuries, which leads to organ dysfunction. The …

Fibrosis refers to the excessive deposition of extracellular matrix components in the
processes of wound repair or tissue regeneration after tissue damage. Fibrosis occurs in …

Epithelial-mesenchymal transition (EMT) is described as the process in which injured renal
tubular epithelial cells undergo a phenotype change, acquiring mesenchymal characteristics …

Abstract Thioredoxin-interacting protein (TXNIP), which is also known as thioredoxin-binding
protein 2 (TBP2), directly interacts with the major antioxidant protein thioredoxin (TRX) and …

Amplification of oxidative stress is present since the early stages of chronic kidney disease
(CKD), holding a key position in the pathogenesis of renal failure. Induction of renal pro …

Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases
(CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all …

Diabetic nephropathy (DN) is the most common chronic kidney disease. Accumulation of
glucose and metabolites activates resident macrophages in kidneys. Resident macrophages …

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease globally. The
primary initiating mechanism in DN is hyperglycemia-induced vascular dysfunction, but its …

Diabetes prevalence is increasing worldwide, especially through the increase of type 2
diabetes. Diabetic nephropathy occurs in up to 40% of diabetic patients and is the leading …