[HTML][HTML] Relieving metabolic burden to improve robustness and bioproduction by industrial microorganisms

J Mao, H Zhang, Y Chen, L Wei, J Liu, J Nielsen… - Biotechnology …, 2024 - Elsevier
Metabolic burden is defined by the influence of genetic manipulation and environmental
perturbations on the distribution of cellular resources. The rewiring of microbial metabolism …

[HTML][HTML] Sustainable production of a biotechnologically relevant β-galactosidase in Escherichia coli cells using crude glycerol and cheese whey permeate

B Greta, P Alex, A Diletta, S Samuele, N Antonino… - Bioresource …, 2024 - Elsevier
Responsible use of natural resources and waste reduction are key concepts in bioeconomy.
This study demonstrates that agro-food derived-biomasses from the Italian food industry …

A comprehensive study of glucose and oxygen gradients in a scaled-down model of recombinant HuGM-CSF production in thermoinduced Escherichia coli fed-batch …

GI Reynoso-Cereceda, NA Valdez-Cruz… - Preparative …, 2024 - Taylor & Francis
The effect of gradients of elevated glucose and low dissolved oxygen in the addition zone of
fed-batch E. coli thermoinduced recombinant high cell density cultures can be evaluated …

A portable and dual-inducible control system for multistep biosynthetic pathways in Gram-negative bacteria

AFC Rincón, AJ Cabral, A Gyorgy, NG Farny - bioRxiv, 2024 - biorxiv.org
The successful production of industrially relevant natural products hinges on two key factors:
the cultivation of robust microbial chassis capable of synthesizing the desired compounds …