[HTML][HTML] Transcriptomic and proteomic investigation of the ameliorative effect of total polyphenolic glycoside extract on hepatic fibrosis in Lamiophlomis rotata Kudo via …

C Yang, X Geng, G Wan, L Song, Y Wang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance During the regression of liver fibrosis, a decrease in
hepatic stellate cells (HSCs) can occur through apoptosis or inactivation of activated HSCs …

Research progress on the role of extracellular vesicles in the pathogenesis of diabetic kidney disease

J Jin, M Zhang - Renal Failure, 2024 - Taylor & Francis
Diabetic kidney disease (DKD) is a serious complication of diabetes mellitus (DM) and has
become the main cause of end-stage renal disease worldwide. In recent years, with the …

Polystyrene microplastics facilitate renal fibrosis through accelerating tubular epithelial cell senescence

C Pan, X Wang, Z Fan, W Mao, Y Shi, Y Wu… - Food and Chemical …, 2024 - Elsevier
Abstract Microplastics (MPs), emerging contaminants, are easily transported and enriched in
the kidney, suggesting the kidney is susceptible to the toxicity of MPs. In this study, we …

Sodium aescinate induces renal toxicity by promoting Nrf2/GPX4-mediated ferroptosis

H Zhu, Y Duan, Y Yang, E Chen, H Huang… - Chemico-Biological …, 2024 - Elsevier
Sodium aescinate (SA) is extracted from Aesculus wilsonii Rehd seeds and was first
marketed as a medicament in German. With the wide application of SA in clinical practice …

Protective effects of Maillard products of skipjack trypsin hydrolysate on uric acid-induced injury of human kidney-2 cell (HK-2)

Y Chu, J Wang, J Sun, R Song, L Chen… - CyTA-Journal of …, 2024 - Taylor & Francis
The uric acid (UA) induced damage influences human health and deserves attention. The
purpose of this study was to investigate the protective effects of Skipjack trypsin hydrolysate …

Targeted delivery of type I TGF-β receptor-mimicking peptide to fibrotic kidney for improving kidney fibrosis therapy via enhancing the inhibition of TGF-β1/Smad and …

X Wang, X Liu, L Xu, Y Li, B Zheng, C Xia… - International …, 2024 - Elsevier
Renal fibrosis is a representative pathological feature of various chronic kidney diseases,
and efficient treatment is needed. Interstitial myofibroblasts are a key driver of kidney …

[PDF][PDF] An Integrated Analysis of Network Pharmacology and Molecular Docking to Explore the Active Component and the Underlying Mechanism of Cuscutae Semen …

Y Lai, B Liang, M Li, Z Lin, T Duan - of, 2023 - researchgate.net
Aims/purpose: To analyze the bioactive components of Cuscutae Semen, the targets and the
underlying mechanism in Cuscutae Semen against Membranous Nephropathy (MN), to …

Exosomes on the development and progression of renal fibrosis

P Wang, W Chen, B Li, S Yang, W Li, S Zhao, J Ning… - Cell … - Wiley Online Library
Renal fibrosis is a prevalent pathological alteration that occurs throughout the progression of
primary and secondary renal disorders towards end‐stage renal disease. As a complex and …