Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has
increased. This review article summarises information on intranasal administration for local …

Reports on the modulatory role of the neuropeptide oxytocin on social cognition and
behavior have steadily increased over the last two decades, stimulating considerable …

The neural basis of abnormal social behavior in autism spectrum disorders (ASDs) remains
incompletely understood. Here we used two complementary but independent brain-wide …

Could nose-to-brain pathways mediate the effects of peptides such as oxytocin (OT) on brain
physiology when delivered intranasally? We address this question by contrasting two …

While the intranasal administration of drugs to the brain has been gaining both research
attention and regulatory success over the past several years, key fundamental and …

Oxytocin (OT) is a neurohypophysial hormone and neuropeptide produced by the
hypothalamus and released by the pituitary gland. It has multiple physiological roles …

Oxytocin, a neuropeptide synthesized by the hypothalamus, plays a central role in human
social behavior, social cognition, anxiety, mood, stress modulation, and fear learning and …

There is a growing number of biomolecules, including peptides, proteins, monoclonal
antibodies and RNA, that could be potentially used for the treatment of central nervous …

Oxytocin (OXT) and arginine-vasopressin (AVP) are structurally homologous peptide
hormones synthesized in the hypothalamus. Nowadays, the role of OXT and AVP in the …

Alzheimer's disease (AD) is characterized by neurodegeneration, memory loss, and social
withdrawal. Brain inflammation has emerged as a key pathogenic mechanism in AD. We …