BACKGROUND: Cigarette smoke–induced chronic obstructive pulmonary disease (COPD)
is a life-threatening inflammatory disorder of the lung. The development of effective …

Background Previous studies have shown a high prevalence of bronchiectasis in patients
with moderate to severe COPD. However, the factors associated with bronchiectasis remain …

Relationships between high-resolution computed tomography (HRCT) findings in chronic
obstructive pulmonary disease (COPD) and bacterial colonization, airway inflammation, or …

Computed tomography scan images have been used to identify different radiological COPD
phenotypes based on the presence and severity of emphysema, bronchial wall thickening …

Chronic obstructive pulmonary disease (COPD) is a prevalent, heterogeneous disorder with
varying presentation and progression but with a limited number of disease-modifying …

The normal lung has several defence mechanisms to deal with microorganisms. Lower
respiratory infections in the absence of lung disease are therefore relatively infrequent as …

Rationale: Inflammation is now recognized as an integral part of the pathogenesis of chronic
obstructive pulmonary disease (COPD). In contrast to the sterile airways of normal lungs …

Background Prevalence and load of airway bacteria in stable and exacerbated chronic
obstructive pulmonary disease (COPD) has been previously studied using microbiological …

Rationale: Treatment of chronic obstructive pulmonary disease (COPD) with inhaled
corticosteroids (ICS) is controversial, because it can reduce the risk of future exacerbations …

Oxidative stress has been implicated in the pathogenesis and progression of chronic
obstructive pulmonary disease. Both reactive oxidant species from inhaled cigarette smoke …