Lung microbiology and exacerbations in COPD

V Beasley, PV Joshi, A Singanayagam… - … journal of chronic …, 2012 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is the most common chronic respiratory
condition in adults and is characterized by progressive airflow limitation that is not fully …

[PDF][PDF] Pneumonia in patients with chronic obstructive pulmonary disease

MI Restrepo, O Sibila… - … and respiratory diseases, 2018 - synapse.koreamed.org
Chronic obstructive pulmonary disease (COPD) is a frequent comorbid condition associated
with increased morbidity and mortality. Pneumonia is the most common infectious disease …

Chronic obstructive pulmonary disease and asthma‐associated Proteobacteria, but not commensal Prevotella spp., promote Toll‐like receptor 2‐independent lung …

JM Larsen, HS Musavian, TM Butt, C Ingvorsen… - …, 2015 - Wiley Online Library
Recent studies of healthy human airways have revealed colonization by a distinct
commensal bacterial microbiota containing Gram‐negative Prevotella spp. However, the …

COPD: current therapeutic interventions and future approaches

PJ Barnes, RA Stockley - European Respiratory Journal, 2005 - Eur Respiratory Soc
Although long-acting bronchodilators have been an important advance for the management
of chronic obstructive pulmonary disease (COPD), these drugs do not deal with the …

[HTML][HTML] Pseudomonas aeruginosa and risk of death and exacerbations in patients with chronic obstructive pulmonary disease: an observational cohort study of 22 …

J Eklöf, R Sørensen, TS Ingebrigtsen… - Clinical Microbiology …, 2020 - Elsevier
Abstract Objectives The role of Pseudomonas aeruginosa in the long-term prognosis of
chronic obstructive pulmonary disease (COPD) is unknown. The purpose of this study was to …

Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages

KBR Belchamber, R Singh, CM Batista… - European …, 2019 - Eur Respiratory Soc
Increased reactive oxygen species (ROS) have been implicated in the pathophysiology of
chronic obstructive pulmonary disease (COPD). This study examined the effect of …

[HTML][HTML] Pulsed moxifloxacin for the prevention of exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial

S Sethi, PW Jones, MS Theron, M Miravitlles… - Respiratory …, 2010 - Springer
Background Acute exacerbations contribute to the morbidity and mortality associated with
chronic obstructive pulmonary disease (COPD). This proof-of-concept study evaluates …

Impaired Phagocytosis of Nontypeable Haemophilus influenzae by Human Alveolar Macrophages in Chronic Obstructive Pulmonary Disease

CS Berenson, MA Garlipp, LJ Grove… - The Journal of …, 2006 - academic.oup.com
Abstract Background Interactions of nontypeable Haemophilus influenzae (NTHI) with
human alveolar macrophages are implicated in the persistence of NTHI in chronic …

[HTML][HTML] Neutrophil extracellular traps in airway diseases: Pathological roles and therapeutic implications

A Jo, DW Kim - International Journal of Molecular Sciences, 2023 - mdpi.com
Neutrophils are important effector cells of the innate immune response that fight pathogens
by phagocytosis and degranulation. Neutrophil extracellular traps (NETs) are released into …

Association of Chronic Obstructive Pulmonary Disease Severity and Pneumocystis Colonization

A Morris, FC Sciurba, IP Lebedeva… - American journal of …, 2004 - atsjournals.org
Factors modulating the variable progression of chronic obstructive pulmonary disease
(COPD) are largely unknown, but infectious agents may play a role. Because Pneumocystis …