Chronic obstructive pulmonary disease (COPD) patients experiencing frequent
exacerbations demonstrate increased stable-state airway inflammation. Tiotropium has …

Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by impaired
clearance of pulmonary bacteria. Objectives: The effect of COPD on alveolar macrophage …

Background. Exposure to tobacco smoke is associated with higher risk of Streptococcus
pneumoniae and Haemophilus influenzae infection. The aim of this study was to determine …

Chronic obstructive pulmonary disease (COPD) is characterised by sputum production,
bacterial colonisation, neutrophilic bronchial airway inflammation and poor health status …

Inhaled antibiotics dramatically improve targeting of drug to the site of respiratory infections,
while simultaneously minimizing systemic exposure and associated toxicity. The high local …

Background Chronic obstructive pulmonary disease (COPD) is a prevalent, progressive
respiratory disease, and acute exacerbations of COPD (AECOPD) can accelerate the …

The importance of the underlying local and systemic oxidative stress and inflammation in
chronic obstructive pulmonary disease (COPD) has long been established. In view of the …

In the healthy lung, macrophages maintain homeostasis by clearing inhaled particles,
bacteria, and removing apoptotic cells from the local pulmonary environment. However, in …

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality
in developed countries, and its prevalence is projected to increase over the coming …

Background Chronic obstructive pulmonary disease (COPD) is a progressive, life-
threatening lung disease with increasing prevalence and incidence worldwide. Increasing …