Stroke treatment: Is exosome therapy superior to stem cell therapy?

Y Cai, W Liu, L Lian, Y Xu, X Bai, S Xu, J Zhang - Biochimie, 2020 - Elsevier
Stroke is one of the most common causes of disability and death, and currently, ideal clinical
treatment is lacking. Stem cell transplantation is a widely-used treatment approach for …

The role and therapeutic potential of exosomes in ischemic stroke

JY Li, QQ Li, R Sheng - Neurochemistry International, 2021 - Elsevier
Ischemic stroke is a disease caused by insufficient blood and oxygen supply to the brain,
which is mainly due to intracranial arterial stenosis and middle cerebral artery occlusion …

[HTML][HTML] Tat-NTS peptide protects neurons against cerebral ischemia-reperfusion injury via ANXA1 SUMOylation in microglia

H Zhou, L Yan, H Huang, X Li, Q Xia, L Zheng… - Theranostics, 2023 - ncbi.nlm.nih.gov
Rationale: Recent studies indicate that microglial activation and the resulting inflammatory
response could be potential targets of adjuvant therapy for ischemic stroke. Many studies …

The Society of Vascular and Interventional Neurology (SVIN) mechanical thrombectomy registry: methods and primary results

DC Haussen, AR Al‐Bayati… - Stroke: Vascular and …, 2022 - Am Heart Assoc
Background A better understanding of real‐world practice patterns in the endovascular
treatment for large vessel occlusion acute ischemic stroke is needed. Here, we report the …

[HTML][HTML] NLRP3 inflammasome deficiency attenuates cerebral ischemia-reperfusion injury by inhibiting ferroptosis

Z Wang, Y Li, Y Ye, H Zhu, J Zhang, H Wang, J Lei… - Brain research …, 2023 - Elsevier
Background The role of ferroptosis in ischemic stroke has been hotly debated recently, but
the mechanism is not clearly clarified. It has been reported that the NLRP3 inflammasome is …

[HTML][HTML] Immunomodulation: The next target of mesenchymal stem cell-derived exosomes in the context of ischemic stroke

XQ Shan, YY Luo, J Chang, JJ Song… - World journal of stem …, 2023 - ncbi.nlm.nih.gov
Ischemic stroke (IS) is the most prevalent form of brain disease, characterized by high
morbidity, disability, and mortality. However, there is still a lack of ideal prevention and …

Red blood cell distribution width to platelet ratio predicts early neurological deterioration in acute ischemic stroke patients receiving intravenous thrombolysis

M Jiang, J Shen, B Muhammad, D Geng - Journal of Stroke and …, 2023 - Elsevier
Background Inflammation plays a prominent role in the pathogenesis and progression of
acute ischemic stroke (AIS). The red blood cell distribution width to platelet ratio (RPR) has …

Neuronal Serpina3n is an endogenous protector against blood brain barrier damage following cerebral ischemic stroke

F Li, Y Zhang, R Li, Y Li, S Ding… - Journal of Cerebral …, 2023 - journals.sagepub.com
Ischemic stroke results in blood-brain barrier (BBB) disruption, during which the reciprocal
interaction between ischemic neurons and components of the BBB appears to play a critical …

Elevated serum lactate dehydrogenase predicts unfavorable outcomes after rt-PA thrombolysis in ischemic stroke patients

H Jin, R Bi, J Hu, D Xu, Y Su, M Huang, Q Peng… - Frontiers in …, 2022 - frontiersin.org
Background and Purpose Currently, acute ischemic stroke (AIS) is one of the most common
and serious diseases in the world and is associated with very high mortality and morbidity …

Oxidative stress as a bridge between age and stroke: A narrative review

S Feng, M Yang, S Liu, Y He, S Deng… - Journal of Intensive …, 2023 - mednexus.org
Stroke is the third most common cause of death globally and a leading cause of disability.
The cellular and molecular changes following stroke and causes of neuronal death are not …