Abstract Silent information regulator 1 (SIRT1), a highly conserved NAD+-dependent
deacetylase, is a cellular regulator that has received extensive attention in recent years and …

Diabetes mellitus (DM) is one of the principal manifestations of metabolic syndrome and its
prevalence with modern lifestyle is increasing incessantly. Chronic hyperglycemia can …

The selection of liver transplant candidates with hepatocellular carcinoma (HCC) relies
mostly on tumor size and number. Instead of relying on these factors, we used poor tumor …

Maternal overnutrition increases the risk of long-term metabolic dysfunction in offspring.
Exercise improves metabolism partly by upregulating mitochondrial biogenesis or function …

Abstract Activation of Sirtuin1 (Sirt1), an nicotinamide adenine dinucleotide oxidized-
dependent deacetylase, by natural or synthetic compounds like resveratrol, SRT2104, or …

Aims/hypothesis The mechanisms underlying the cellular metabolic memory induced by
high glucose remain unclear. Here, we sought to determine the effects of microRNAs …

Accumulating evidence has demonstrated that epigenetic modification-mediated changes in
pain-related gene expressions play an important role in the development and maintenance …

Sirtuin1 (Sirt1; mammalian homolog of Saccharomyces cerevisiae enzyme Sir2) is a
transcriptional and transactivational regulator of murine farnesoid X receptor (Fxr), which is …

Biology | Free Full-Text | Sirtuins-Mediated System-Level Regulation of Mammalian Tissues at
the Interface between Metabolism and Cell Cycle: A Systematic Review Next Article in Journal …

Obesity-induced insulin resistance is the principal cause of type 2 diabetes worldwide. The
use of natural products for the treatment of diabetes is increasingly attracting attention …