[HTML][HTML] Production of l-glutamate family amino acids in Corynebacterium glutamicum: physiological mechanism, genetic modulation, and prospects

Q Sheng, XY Wu, X Xu, X Tan, Z Li, B Zhang - Synthetic and Systems …, 2021 - Elsevier
Abstract l-glutamate family amino acids (GFAAs), consisting of l-glutamate, l-arginine, l-
citrulline, l-ornithine, l-proline, l-hydroxyproline, γ-aminobutyric acid, and 5-aminolevulinic …

A genome-based approach to create a minimally mutated Corynebacterium glutamicum strain for efficient l-lysine production

M Ikeda, J Ohnishi, M Hayashi… - Journal of industrial …, 2006 - academic.oup.com
Based on the progress in genomics, we have developed a novel approach that employs
genomic information to generate an efficient amino acid producer. A comparative genomic …

[HTML][HTML] Synthetic biology tools for engineering Corynebacterium glutamicum

GY Kim, J Kim, G Park, HJ Kim, J Yang… - Computational and …, 2023 - Elsevier
Corynebacterium glutamicum is a promising organism for the industrial production of amino
acids, fuels, and various value-added chemicals. From the whole genome sequence …

The l-Lysine Story: From Metabolic Pathways to Industrial Production

C Wittmann, J Becker - Amino Acid Biosynthesis~ Pathways, Regulation …, 2007 - Springer
Abstract l-lysine is an essential amino acid required for nutrition of animals and humans. It
has to be present in food and feed, which, in many cases, is realized by supplementation of …

[HTML][HTML] Development and experimental verification of a genome-scale metabolic model for Corynebacterium glutamicum

Y Shinfuku, N Sorpitiporn, M Sono, C Furusawa… - Microbial cell …, 2009 - Springer
Background In silico genome-scale metabolic models enable the analysis of the
characteristics of metabolic systems of organisms. In this study, we reconstructed a genome …

[HTML][HTML] Metabolic engineering of Corynebacterium glutamicum aimed at alternative carbon sources and new products

A Zahoor, SN Lindner, VF Wendisch - Computational and structural …, 2012 - Elsevier
Corynebacterium glutamicum is well known as the amino acid-producing workhorse of
fermentation industry, being used for multi-million-ton scale production of glutamate and …

Reengineering of a Corynebacterium glutamicuml-Arginine and l-Citrulline Producer

M Ikeda, S Mitsuhashi, K Tanaka… - Applied and …, 2009 - Am Soc Microbiol
Toward the creation of a robust and efficient producer of l-arginine and l-citrulline
(arginine/citrulline), we have performed reengineering of a Corynebacterium glutamicum …

clpC and clpP1P2 gene expression in Corynebacterium glutamicum is controlled by a regulatory network involving the transcriptional regulators ClgR and HspR as well as the …

S Engels, JE Schweitzer, C Ludwig, M Bott… - Molecular …, 2004 - Wiley Online Library
The ATP‐dependent protease Clp plays important roles in the cell's protein quality control
system and in the regulation of cellular processes. In Corynebacterium glutamicum, the …

Production of l-Lysine from starch by Corynebacterium glutamicum displaying α-amylase on its cell surface

T Tateno, H Fukuda, A Kondo - Applied microbiology and biotechnology, 2007 - Springer
We engineered a Corynebacterium glutamicum strain displaying α-amylase from
Streptococcus bovis 148 (AmyA) on its cell surface to produce amino acids directly from …

[HTML][HTML] Arsenate reductase, mycothiol, and mycoredoxin concert thiol/disulfide exchange

E Ordóñez, K Van Belle, G Roos, S De Galan… - Journal of Biological …, 2009 - ASBMB
We identified the first enzymes that use mycothiol and mycoredoxin in a thiol/disulfide redox
cascade. The enzymes are two arsenate reductases from Corynebacterium glutamicum …