Biosynthesis of the three aromatic amino acids (l-phenylalanine, l-trypto phan, l-tyrosine)
and its regulation in Escherichia coli and corynebacteria are reviewed. The common …

A central goal of systems biology is the elucidation of cell function and physiology through
the integrated use of broad based genomic and physiological data. Such systemic …

Toward the elucidation of the advanced mechanism of l-valine production by
Corynebacterium glutamicum, a highly developed industrial strain VWB-1 was analyzed …

We have recently developed a Corynebacterium glutamicum strain that generates NADPH
via the glycolytic pathway by replacing endogenous NAD-dependent glyceraldehyde 3 …

During the half century following its discovery, the l-glutamate-producing microorganism
Corynebacterium glutamicum has played a leading role in the amino acid fermentation …

The genes involved in gluconate catabolism (gntP and gntK) in Corynebacterium
glutamicum are scattered in the chromosome, and no regulatory genes are apparently …

Systems biology is attracting significant interest finding applications not only in
pharmaceutical development but also for basic studies on microbial systems. The latter often …

Corynebacterineae is a specific suborder of Gram-positive bacteria that includes
Mycobacterium tuberculosis and Corynebacterium glutamicum. The cell wall of these …

Abstract γ-Aminobutyric acid (GABA), a non-protein amino acid, is a bioactive component in
the food, feed and pharmaceutical fields. To establish an effective single-step production …

Oxygen limitation is a crucial problem in amino acid fermentation by Corynebacterium
glutamicum. Toward this subject, our study was initiated by analysis of the oxygen-requiring …