Long COVID as a Disease of Accelerated Biological Aging: An Opportunity to Translate Geroscience Interventions

A Shafqat, MC Masters, U Tripathi, T Tchkonia… - Ageing Research …, 2024 - Elsevier
It has been four years since long COVID—the protracted consequences that survivors of
COVID-19 face—was first described. Yet, this entity continues to devastate the quality of life …

[HTML][HTML] COVID-19 related neurological manifestations in Parkinson's disease: has ferroptosis been a suspect?

F Jia, J Han - Cell Death Discovery, 2024 - nature.com
A rising number of patient cases point to a probable link between SARS-CoV-2 infection and
Parkinson's disease (PD), yet the mechanisms by which SARS-CoV-2 affects the brain and …

SARS and synapses

HA Gelbard, W Chiang - Nature Microbiology, 2024 - nature.com
SARS and synapses | Nature Microbiology Skip to main content Thank you for visiting nature.com.
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Inflammatory response and defects on myelin integrity in the olfactory system of K18hACE2 mice infected with SARS-CoV-2

E Martin-Lopez, B Brennan, T Mao, N Spence… - eneuro, 2024 - eneuro.org
Viruses, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), use
respiratory epithelial cells as an entry point for infection. Within the nasal cavity, the olfactory …

[HTML][HTML] Histochemical Evidence for Reduced Immune Response in Nasal Mucosa of Patients with COVID-19

N Power Guerra, M Bierkämper, J Pablik… - International Journal of …, 2024 - mdpi.com
The primary entry point of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
is the nasal mucosa, where viral-induced inflammation occurs. When the immune response …

Cytoskeletal β-tubulin and cysteine cathepsin L deregulation by SARS-CoV-2 spike protein interaction with the neuronal model cell line SH-SY5Y

BR Oliveira, I Nehlmeier, AM Kempf, V Venugopalan… - Biochimie, 2024 - Elsevier
SARS-CoV-2 mainly infects the respiratory tract but can also target other organs, including
the central nervous system. While it was recently shown that cells of the blood-brain-barrier …

The Molecular Basis of Olfactory Dysfunction in COVID-19 and Long COVID

C Anastassopoulou, N Davaris, S Ferous… - Lifestyle …, 2024 - karger.com
Olfactory dysfunction (OD) is not uncommon following viral infection. Herein, we explore the
interplay of host genetics with viral correlates in coronavirus disease 2019 (COVID-19)-and …

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

Y Qiu, C Mo, L Chen, W Ye, G Chen, T Zhu - MedComm, 2024 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) recently caused a global
pandemic, resulting in more than 702 million people being infected and over 6.9 million …

[HTML][HTML] A study of the protease inhibitory activity component of SARS-CoV-2 3CL in Bletilla striata

Y Yang, F Zhang, S Liu, W Jin, Q Shao, C Li… - Frontiers in Natural …, 2024 - frontiersin.org
The protease Mpro (referred to as 3CLpro or 3CL protease) is a cysteine protease that is
highly conserved in coronavirus and is indispensable for viral replication. Because there is …

[HTML][HTML] Post-COVID cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction: national prospective …

B Michael, G Wood, B Sargent, K Tharmaratnam… - 2024 - researchsquare.com
The spectrum, pathophysiology, and recovery trajectory of persistent post-COVID-19
cognitive deficits are unknown, limiting our ability to develop prevention and treatment …