[HTML][HTML] Linking the Amyloid, Tau, and Mitochondrial Hypotheses of Alzheimer's Disease and Identifying Promising Drug Targets

Z Fišar - Biomolecules, 2022 - mdpi.com
Damage or loss of brain cells and impaired neurochemistry, neurogenesis, and synaptic and
nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as …

[HTML][HTML] New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs)

CP Palanisamy, JJ Pei, P Alugoju, NVA Anthikapalli… - Theranostics, 2023 - ncbi.nlm.nih.gov
Neurodegenerative diseases are characterized by the progressive loss of neurons and
intricate interactions between different cell types within the affected regions. Reliable …

Matrine-induced nephrotoxicity via GSK-3β/nrf2-mediated mitochondria-dependent apoptosis

T Wang, J Zhang, H Wei, X Wang, M Xie, Y Jiang… - Chemico-Biological …, 2023 - Elsevier
Introduction Matrine (MT), an ingredient extracted from the Chinese herb Sophora
flavescens, can result in nephrotoxicity because of long-term exposure. However, the …

[HTML][HTML] Therapeutic potential of targeting mitochondria for Alzheimer's disease treatment

A Atlante, G Amadoro, V Latina, D Valenti - Journal of Clinical Medicine, 2022 - mdpi.com
Alzheimer's disease (AD), a chronic and progressive neurodegenerative disease, is
characterized by memory and cognitive impairment and by the accumulation in the brain of …

[PDF][PDF] Transcriptome analysis identifies the role of Class I histone deacetylase in Alzheimer's disease

F Geng, N Zhao, X Chen, XT Liu, MM Zhu, Y Jiang… - Heliyon, 2023 - cell.com
Epigenetics modification is a process that does not change the sequence of
deoxyribonucleic acid (DNA) in disease progression but can alter the genetic expression of …

[HTML][HTML] Ketogenic diet alleviates cognitive dysfunction and neuroinflammation in APP/PS1 mice via the Nrf2/HO-1 and NF-κB signaling pathways

J Jiang, H Pan, F Shen, Y Tan… - Neural Regeneration …, 2023 - journals.lww.com
Alzheimer's disease is a progressive neurological disorder characterized by cognitive
decline and chronic inflammation within the brain. The ketogenic diet, a widely recognized …

Multifaceted roles of mitochondrial dysfunction in diseases: from powerhouses to saboteurs

SS Prabhu, AS Nair, SV Nirmala - Archives of Pharmacal Research, 2023 - Springer
The fact that mitochondria play a crucial part in energy generation has led to the nickname
“powerhouses” of the cell being applied to them. They also play a significant role in many …

Fabrication and characterization of Hypecoum pendulum‐assisted novel bio‐inspired silver nanoparticles and their antioxidant, anti‐diabetic, and anti‐Alzheimer …

NU Huda, M Ahmed, N Mushtaq… - Applied Organometallic …, 2023 - Wiley Online Library
This research aims to study the biogenic synthesis and characterization of Hypecoum
pendulum extract‐induced silver nanoparticles (HP‐AgNPs) and to investigate its …

Understanding the mechanisms of disease modifying effects of aerobic exercise in people with Alzheimer's disease

A Abdullahi, TWL Wong, SSM Ng - Ageing Research Reviews, 2024 - Elsevier
Alzheimer's disease (AD) is a very disabling disease. Pathologically, it is characterized by
the presence of amyloid plaques and neurofibrillary tangles in the brain that results in …

[HTML][HTML] Mitochondrial Complex I and β-Amyloid Peptide Interplay in Alzheimer's Disease: A Critical Review of New and Old Little Regarded Findings

A Atlante, D Valenti - International Journal of Molecular Sciences, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common neurodegenerative disorder and the main
cause of dementia which is characterized by a progressive cognitive decline that severely …