Antimicrobial agents play a key role in controlling and curing infectious disease. Soon after
the discovery of the first antibiotic, the challenge of antibiotic resistance commenced …

Importance β-Lactam antibiotics are among the safest and most effective antibiotics. Many
patients report allergies to these drugs that limit their use, resulting in the use of broad …

Background Treating patients with infections due to multidrug-resistant pathogens often
requires substantial healthcare resources. The purpose of this study was to report estimates …

Abstract Background Efforts to prevent Clostridioides difficile infection continue to expand
across the health care spectrum in the United States. Whether these efforts are reducing the …

The occurrence of antibiotics and antibiotic resistance genes in riverine systems has
become a growing concern worldwide. Risk prediction of antibiotic resistance is difficult as …

Lower respiratory tract infections (LRTIs) lead to more deaths each year than any other
infectious disease category. Despite this, etiologic LRTI pathogens are infrequently …

The gut microbiome is now considered an organ unto itself and plays an important role in
health maintenance and recovery from critical illness. The commensal organisms …

Antibiotic-resistant infections are a global health care concern. The Centers for Disease
Control and Prevention estimates that 23,000 Americans with these infections die each year …

Importance Hospital antimicrobial consumption data are widely available; however, large-
scale assessments of the quality of antimicrobial use in US hospitals are limited. Objective …

Aquatic ecosystems subjected to anthropogenic pressures are places of rapid evolution of
microbial communities and likely hotspots for selection and emergence of antibiotic resistant …