The influence of cell cycle regulation on chemotherapy
Y Sun, Y Liu, X Ma, H Hu - International journal of molecular sciences, 2021 - mdpi.com
Cell cycle regulation is orchestrated by a complex network of interactions between proteins,
enzymes, cytokines, and cell cycle signaling pathways, and is vital for cell proliferation …
enzymes, cytokines, and cell cycle signaling pathways, and is vital for cell proliferation …
CRISPR/Cas: a Nobel Prize award-winning precise genome editing technology for gene therapy and crop improvement
Since it was first recognized in bacteria and archaea as a mechanism for innate viral
immunity in the early 2010s, clustered regularly interspaced short palindromic repeats …
immunity in the early 2010s, clustered regularly interspaced short palindromic repeats …
Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain
J Gallego-Bartolomé, J Gardiner… - Proceedings of the …, 2018 - National Acad Sciences
DNA methylation is an important epigenetic modification involved in gene regulation and
transposable element silencing. Changes in DNA methylation can be heritable and, thus …
transposable element silencing. Changes in DNA methylation can be heritable and, thus …
Staying true to yourself: mechanisms of DNA methylation maintenance in mammals
DNA methylation is essential to development and cellular physiology in mammals. Faulty
DNA methylation is frequently observed in human diseases like cancer and neurological …
DNA methylation is frequently observed in human diseases like cancer and neurological …
DNA methylation dynamics during early plant life
D Bouyer, A Kramdi, M Kassam, M Heese, A Schnittger… - Genome biology, 2017 - Springer
Background Cytosine methylation is crucial for gene regulation and silencing of
transposable elements in mammals and plants. While this epigenetic mark is extensively …
transposable elements in mammals and plants. While this epigenetic mark is extensively …
Methionine metabolism in chronic liver diseases: an update on molecular mechanism and therapeutic implication
Z Li, F Wang, B Liang, Y Su, S Sun, S Xia… - Signal transduction and …, 2020 - nature.com
As one of the bicyclic metabolic pathways of one-carbon metabolism, methionine
metabolism is the pivot linking the folate cycle to the transsulfuration pathway. In addition to …
metabolism is the pivot linking the folate cycle to the transsulfuration pathway. In addition to …
Retention of paternal DNA methylome in the developing zebrafish germline
K Skvortsova, K Tarbashevich, M Stehling… - Nature …, 2019 - nature.com
Two waves of DNA methylation reprogramming occur during mammalian embryogenesis;
during preimplantation development and during primordial germ cell (PGC) formation …
during preimplantation development and during primordial germ cell (PGC) formation …
HiTIMED: hierarchical tumor immune microenvironment epigenetic deconvolution for accurate cell type resolution in the tumor microenvironment using tumor-type …
Background Cellular compositions of solid tumor microenvironments are heterogeneous,
varying across patients and tumor types. High-resolution profiling of the tumor …
varying across patients and tumor types. High-resolution profiling of the tumor …
Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL
The ability of a cell to dynamically switch its chromatin between different functional states
constitutes a key mechanism regulating gene expression. Histone mark “readers” display …
constitutes a key mechanism regulating gene expression. Histone mark “readers” display …
TET-mediated epigenetic regulation in immune cell development and disease
NJ Tsiouplis, DW Bailey, LF Chiou… - Frontiers in Cell and …, 2021 - frontiersin.org
TET proteins oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and further
oxidation products in DNA. The oxidized methylcytosines (oxi-mCs) facilitate DNA …
oxidation products in DNA. The oxidized methylcytosines (oxi-mCs) facilitate DNA …