Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: an update on current advances and …

MU Rehman, N Sehar, NJ Dar, A Khan, A Arafah… - Neuroscience & …, 2023 - Elsevier
Neurodegenerative diseases (NDs) such as Alzheimer disease (AD), Parkinson disease
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …

The potential of hyperbaric oxygen as a therapy for neurodegenerative diseases

P Mensah-Kane, N Sumien - GeroScience, 2023 - Springer
Abstract The World Health Organization estimates that by the year 2040, neurodegenerative
diseases will be the second leading cause of death in developed countries, overtaking …

Peroxisom proliferator-activated receptor-γ coactivator-1α in neurodegenerative disorders: A promising therapeutic target

YN Yang, MQ Zhang, FL Yu, B Han, MY Bao… - Biochemical …, 2023 - Elsevier
Neurodegenerative disorders (NDDs) are characterized by progressive loss of selectively
vulnerable neuronal populations and myelin sheath, leading to behavioral and cognitive …

The Potential Role of Voltage‐Dependent Anion Channel in the Treatment of Parkinson's Disease

Y He, W Wang, T Yang, ER Thomas… - … Medicine and Cellular …, 2022 - Wiley Online Library
Parkinson's disease (PD) is a neurodegenerative disease second only to Alzheimer's
disease in terms of prevalence. Previous studies have indicated that the occurrence and …

Unveiling the Interplay of AMPK/SIRT1/PGC-1α axis in Brain Health: Promising Targets Against Aging and NDDs

PS Rakshe, BJ Dutta, S Chib, N Maurya… - Ageing Research Reviews, 2024 - Elsevier
The escalating prevalence of neurodegenerative diseases (NDDs) within an aging global
population presents a pressing challenge. The multifaceted pathophysiological mechanisms …

Hyperbaric Oxygen Therapy Attenuated the Motor Coordination and Cognitive Impairment of Polyglutamine Spinocerebellar Ataxia SCA17 Mice

MK Chiang, TC Lin, KH Lin, YC Chang, HM Hsieh-Li… - The Cerebellum, 2024 - Springer
Spinocerebellar ataxias (SCAs) are a large and diverse group of autosomal-dominant
neurodegenerative diseases. No drugs have been approved for these relentlessly …

Effects of high-intensity interval training with hyperbaric oxygen

M Alvarez Villela, SA Dunworth, BD Kraft… - Frontiers in …, 2022 - frontiersin.org
Hyperbaric Oxygen (HBO2) has been proposed as a pre-conditioning method to enhance
exercise performance. Most prior studies testing this effect have been limited by inadequate …

Linalool, a Fragrance Compound in Plants, Protects Dopaminergic Neurons and Improves Motor Function and Skeletal Muscle Strength in Experimental Models of …

WH Chang, HT Hsu, CC Lin, LM An, CH Lee… - International Journal of …, 2024 - mdpi.com
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the
gradual loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) …

Chiisanoside Mediates the Parkin/ZNF746/PGC-1α Axis by Downregulating MiR-181a to Improve Mitochondrial Biogenesis in 6-OHDA-Caused Neurotoxicity Models …

YL Hsu, HJ Chen, JX Gao, MY Yang, RH Fu - Antioxidants, 2023 - mdpi.com
The degeneration of dopamine (DA) neurons is known to be associated with defects in
mitochondrial biogenesis caused by aging, environmental factors, or mutations in genes …

Icariin prevents methylmercury-induced experimental neurotoxicity: Evidence from cerebrospinal fluid, blood plasma, brain samples, and in-silico investigations

S Sharma, S Mehan, Z Khan, GD Gupta, AS Narula - Heliyon, 2024 - cell.com
Abstract Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease that
causes significant neurodegeneration. Methylmercury (MeHg+) is a neurotoxin that induces …