DNA vaccination has been of great interest since its discovery in the 1990s due to its ability
to elicit both humoral and cellular immune responses. DNA vaccines consist of a DNA …

Coccidial parasites cause medical and veterinary diseases worldwide, frequently leading to
severe illness and important economic losses. At present, drugs, chemotherapeutics and …

Augmentation of immunogenicity can be achieved by particulate delivery of an antigen and
by its co-administration with an adjuvant. However, many adjuvants initiate strong systemic …

The advent of mass vaccination has saved millions of human lives and revolutionized the
quality of life. Vaccination is currently one of the most cost effective ways of managing …

Mucosal vaccine delivery systems have paramount importance for the induction of mucosal
antibody responses. Two studies were conducted to evaluate immunogenicity of inactivated …

The lipid calcium phosphate nanoparticle is a versatile platform capable of encapsulating a
wide range of phosphorylated molecules from single nucleotides to pDNA. The use of this …

Initial findings were obtained by JL and MEM and were published in abstract form. PSH and
MEM jointly and interactively led and funded the project; designed the overall direction of the …

Natural or synthetic Toll-like receptor (TLR) ligands trigger innate responses by interacting
with distinct TLRs. TLR ligands can thus serve as vaccine adjuvants or stand-alone …

In subunit vaccines, aluminum salts (Alum) are commonly used as adjuvants, but with limited
cellular immune responses. To overcome this limitation, CpG oligodeoxynucleotides (ODNs) …

We investigated the adjuvant effect of CpG ODN alone or in combination with aluminum
hydroxide on the immune response to the three main antigens presented in current acellular …