Aging is characterized by loss of spinal motor neurons (MNs) due to apoptosis, reduced
insulin‐like growth factor I signaling, elevated amounts of circulating cytokines, and …

Functional and structural decline in the neuromuscular system with aging has been
recognized as a cause of impairment in physical performance and loss of independence in …

Examining neural etiologic factors' role in the decline of neuromuscular function with aging
is essential to our understanding of the mechanisms underlying sarcopenia, the age …

The escalation of life expectancy is accompanied by an increase in the prevalence of age-
related conditions, such as sarcopenia. Sarcopenia, a muscle condition defined by low …

The growth-associated protein B-50 (GAP-43) is a presynaptic protein. Its expression is
largely restricted to the nervous system. B-50 is frequently used as a marker for sprouting …

We here review the loss of muscle function and mass (sarcopenia) in the framework of
human healthspan and lifespan, and mechanisms involved in aging. The rapidly changing …

Pericytes are perivascular cells that envelop and make intimate connections with adjacent
capillary endothelial cells. Recent studies show that they may have a profound impact in …

Motor disturbances and wasting of skeletal muscles (sarcopenia) causes significant
impairment of daily life activities and is a major underlying cause for hospitalization in …

Aged individuals exhibit reduced functional recovery after stroke. We examined the
expression profile in aged animals of a recently identified group of growth-associated genes …

This paper summarizes the various effects of neurotrophins in skeletal muscle and how
these proteins act as potential regulators of the maintenance, function, and regeneration of …