Kinins are proinflammatory peptides that mediate numerous vascular and pain responses to
tissue injury. Two pharmacologically distinct kinin receptor subtypes have been identified …

Kinins are a family of peptides implicated in several pathophysiological events. Most of their
effects are likely mediated by the activation of two G‐protein‐coupled receptors: B1 and B2 …

Patients awaiting lung transplantation face high wait-list mortality, as injury precludes the
use of most donor lungs. Although ex vivo lung perfusion (EVLP) is able to recover marginal …

The anti-inflammatory and anti-allergic effects of the essential oil of Cordia verbenacea
(Boraginaceae) and some of its active compounds were evaluated. Systemic treatment with …

Several studies have now clearly established the ability of LPS to induce bradykinin B 1
receptor up-regulation in vivo and the functional relevance of this up-regulation for the …

The administration of bradykinin may attenuate ischemia and reperfusion (I/R) injury by
acting on B 2 Rs. Blockade of B 2 R has also been shown to ameliorate lesions associated …

Objective: This study evaluates the action of celecoxib and rofecoxib, two selective
cyclooxygenase-2 (COX-2) inhibitors in two acute models of inflammation, carrageenan (Cg) …

Complex regional pain syndrome type 1 (CRPS1) may be evoked by ischemia/reperfusion,
eliciting acute and chronic pain that is difficult to treat. Despite this, the underlying …

Bradykinin and Lys-bradykinin are potent peptide mediators implicated in several
physiopathological effects in mammals. They act through activation of G-protein-coupled …

Vitamin E (vit-E) is a lipophilic antioxidant, and its anti-inflammatory activity is still not full
characterized. Thus, our goal was to investigate the anti-inflammatory effect of repeated vit-E …