The alterations in myocardial energy substrate metabolism that occur in heart failure, and
the causes and consequences of these abnormalities, are poorly understood. There is …

The regulation of mammalian myocardial carbohydrate metabolism is complex in that it is
linked to arterial substrate and hormone levels, coronary flow, inotropic state and the …

There is little doubt that the central areas of traditional biochemistry (such as metabolism,
metabolic regulation and enzymology) are currently unfashionable and generally regarded …

In patients with diabetes, an increased risk of symptomatic heart failure usually develops in
the presence of hypertension or ischemic heart disease. However, a predisposition to heart …

Following a myocardial infarction diabetic patients have almost twice the rate of mortality
and 3 times the rate of progression to congestive heart failure when compared to wx …

METHODS Muscle extracd8. For assay of glucose or pentose heart muscle was extracted
with boiling water as described by Battaglia & Randle (1960). Glycogen synthesis. This was …

Fatty acids represent a very important, if not the most important, substrate for myocardial
energy metabolism. The heart derives fatty acids from circulating FFA bound to albumin and …

D-beta-hydroxybutyrate, the principal" ketone" body in starving man, displaces glucose as
the predominating fuel for brain, decreasing the need for glucose synthesis in liver (and …

This review focuses on the regulation of myocardial fatty acids and glucose metabolism is
physiological and pathological conditions, and the role of L-carnitine and of its derivative …

The mammalian pyruvate dehydrogenase complex (PDH complex) is located in the
mitochondrial inner membrane-matrix space (Schnaitman and Greenawalt 1968, Addink et …