To ensure the high-fidelity transmission of genetic information, cells have evolved
mechanisms to monitor genome integrity. Cells respond to DNA damage by activating a …

Chromosome aberrations, in particular translocations and their corresponding gene fusions,
have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions …

Thyroid carcinomas are fairly uncommon and include disease types that range from indolent
localised papillary carcinomas to the fulminant and lethal anaplastic disease. Several …

Thyroid papillary cancers (PTCs) are associated with activating mutations of genes coding
for RET or TRK tyrosine kinase receptors, as well as of RAS genes. Activating mutations of …

Tumors are being increasingly perceived as abnormal organs that, in many respects,
recapitulate the outgrowth and differentiation patterns of normal tissues. In line with this idea …

Nuclear architecture—the spatial arrangement of chromosomes and other nuclear
components—provides a framework for organizing and regulating the diverse functional …

Thyroid cancer is one of the few malignancies that are increasing in incidence. Recent
advances have improved our understanding of its pathogenesis; these include the …

BACKGROUND An increase in thyroid cancers, predominantly papillary thyroid carcinoma
(PTC), has been recently reported in children. METHODS The histopathology of 28 …

ABSTRACT Objective:(1) Describe current epidemiology of thyroid cancer in the United
States;(2) evaluate hypothesized causes of the increased incidence of thyroid cancer; and …

Summary In Drosophila melanogaster, Hox genes are organized in an anterior and a
posterior cluster, called Antennapedia complex and bithorax complex, located on the same …