DNA double-strand breaks: signaling, repair and the cancer connection
KK Khanna, SP Jackson - Nature genetics, 2001 - nature.com
To ensure the high-fidelity transmission of genetic information, cells have evolved
mechanisms to monitor genome integrity. Cells respond to DNA damage by activating a …
mechanisms to monitor genome integrity. Cells respond to DNA damage by activating a …
The impact of translocations and gene fusions on cancer causation
F Mitelman, B Johansson, F Mertens - Nature Reviews Cancer, 2007 - nature.com
Chromosome aberrations, in particular translocations and their corresponding gene fusions,
have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions …
have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions …
Thyroid carcinoma
SI Sherma - The Lancet, 2003 - thelancet.com
Thyroid carcinomas are fairly uncommon and include disease types that range from indolent
localised papillary carcinomas to the fulminant and lethal anaplastic disease. Several …
localised papillary carcinomas to the fulminant and lethal anaplastic disease. Several …
High Prevalence of BRAF Mutations in Thyroid Cancer: Genetic Evidence for Constitutive Activation of the RET/PTC-RAS-BRAF Signaling Pathway in Papillary …
Thyroid papillary cancers (PTCs) are associated with activating mutations of genes coding
for RET or TRK tyrosine kinase receptors, as well as of RAS genes. Activating mutations of …
for RET or TRK tyrosine kinase receptors, as well as of RAS genes. Activating mutations of …
Cancer stem cell niche: the place to be
T Borovski, F De Sousa E Melo, L Vermeulen… - Cancer research, 2011 - AACR
Tumors are being increasingly perceived as abnormal organs that, in many respects,
recapitulate the outgrowth and differentiation patterns of normal tissues. In line with this idea …
recapitulate the outgrowth and differentiation patterns of normal tissues. In line with this idea …
Nuclear structure in cancer cells
D Zink, AH Fischer, JA Nickerson - Nature reviews cancer, 2004 - nature.com
Nuclear architecture—the spatial arrangement of chromosomes and other nuclear
components—provides a framework for organizing and regulating the diverse functional …
components—provides a framework for organizing and regulating the diverse functional …
Pathogenetic mechanisms in thyroid follicular-cell neoplasia
Thyroid cancer is one of the few malignancies that are increasing in incidence. Recent
advances have improved our understanding of its pathogenesis; these include the …
advances have improved our understanding of its pathogenesis; these include the …
NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States
ML Prasad, M Vyas, MJ Horne, RK Virk, R Morotti… - Cancer, 2016 - Wiley Online Library
BACKGROUND An increase in thyroid cancers, predominantly papillary thyroid carcinoma
(PTC), has been recently reported in children. METHODS The histopathology of 28 …
(PTC), has been recently reported in children. METHODS The histopathology of 28 …
American Association of Clinical Endocrinologists and American College of Endocrinology disease state clinical review: the increasing incidence of thyroid cancer
L Davies, LGT Morris, M Haymart, AY Chen… - Endocrine Practice, 2015 - Elsevier
ABSTRACT Objective:(1) Describe current epidemiology of thyroid cancer in the United
States;(2) evaluate hypothesized causes of the increased incidence of thyroid cancer; and …
States;(2) evaluate hypothesized causes of the increased incidence of thyroid cancer; and …
[HTML][HTML] Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila
F Bantignies, V Roure, I Comet, B Leblanc… - Cell, 2011 - cell.com
Summary In Drosophila melanogaster, Hox genes are organized in an anterior and a
posterior cluster, called Antennapedia complex and bithorax complex, located on the same …
posterior cluster, called Antennapedia complex and bithorax complex, located on the same …