The transmembrane proto‐oncogene receptor tyrosine kinase (RTK) ROS is an orphan
receptor that is aberrantly expressed in neoplasms of the central nervous system. Here, we …

Genomes are organized into complex higher-order structures by folding of the DNA into
chromatin fibers, chromosome domains, and ultimately chromosomes. The higher-order …

Despite the recent discoveries of and interest in numerous structural variations (SVs)—
which include duplications and inversions—in the human and other higher eukaryotic …

TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC);
they arise from the fusion of the 3′ terminal sequences of the NTRK1/NGF receptor gene …

Background: Very little was known about the molecular pathogenesis of thyroid cancer until
the late 1980s. As part of the Centennial celebration of the American Thyroid Association …

Activating mutations of BRAF have been identified in a variety of human cancers, most
notably melanomas and papillary thyroid carcinomas (PTCs). The aim of the present study …

The increase in risk for late-onset thyroid cancer due to radiation exposure is a potential
health effect after a nuclear power plant accident mainly due to the release of radioiodine in …

Radiation is a carcinogen, interacting with DNA to produce a range of mutations. Irradiated
cells also show genomic instability, as do adjacent non-irradiated cells (the bystander …

Hemophilia A, one of the most common genetic bleeding disorders, is caused by various
mutations in the blood coagulation factor VIII (F8) gene. Among the genotypes that result in …

Non-random chromosomal translocations are frequently associated with a variety of
cancers, particularly hematologic malignancies and childhood sarcomas. In addition to their …