We studied the spatiotemporal organization of DNA damage processing by live cell
microscopy analysis in human cells. In unirradiated U2OS osteosarcoma and HeLa cancer …

Chromosomal translocations and genomic instability are universal hallmarks of tumor cells.
While the molecular mechanisms leading to the formation of translocations are rapidly being …

The Chernobyl accident exposed people located hundreds of kilometres away to fallout, but
increases in cancer incidence as a result of the accident seem, at present, to be restricted to …

Recurrent chromosomal translocations are characteristic features of many types of cancers,
especially lymphomas and leukemias. Several basic mechanistic factors are required for the …

Genomes are housed within cell nuclei as individual chromosome territories. Nuclei contain
several architectural structures that interact and influence the genome. In this review, we …

Recurring chromosome abnormalities are strongly associated with certain subtypes of
leukemia, lymphoma and sarcomas. More recently, their potential involvement in …

An increased incidence of thyroid cancer in the exposed children remains the most well-
documented long-term effect of radioactive contamination after the Chernobyl nuclear …

BACKGROUND: Childhood exposure to iodine‐131 from the 1986 nuclear accident in
Chernobyl, Ukraine, led to a sharp increase in papillary thyroid carcinoma (PTC) incidence …

Genomic rearrangements in inherited disease and cancer involve gross alterations of
chromosomes or large chromosomal regions and can take the form of deletions …

Chromosomes exist in the interphase nucleus as individual chromosome territories. It is
unclear to what extent chromosome territories occupy particular positions with respect to …