A salient feature of alcoholic liver disease (ALD) is Kupffer cell (KC) activation and
recruitment of inflammatory monocytes and macrophages (MØs). These key cellular events …

In vivo biodistribution and fate of extracellular vesicles (EVs) are still largely unknown and
require reliable in vivo tracking techniques. In this study, in vivo bioluminescence imaging …

Excessive alcohol consumption is a global healthcare problem with enormous social,
economic, and clinical consequences. While chronic, heavy alcohol consumption causes …

Liver disease is responsible for approximately 1.2 million global deaths per year, which
account for 3.5% of all deaths worldwide.[1] Acute liver injury is often reversible, while …

With the growing number of novel therapeutic approaches for liver diseases, significant
research efforts have been devoted to the development of liquid biopsy tools for precision …

Extracellular vesicles (EVs) are secreted by all living cells and are found in body fluids. They
exert numerous physiological and pathological functions and serve as cargo shuttles. Due to …

Non-alcoholic fatty liver disease (NAFLD) is a challenging disease caused by multiple
factors, which may partly explain why it still remains an orphan of adequate therapies. This …

The liver is an important immunological organ that controls systemic tolerance. The liver
harbors professional and unconventional antigen-presenting cells that are crucial for …

Extracellular vesicles, including exosomes and microvesicles, play a fundamental role in the
activity of the nervous system, participating in signal transmission between neurons and …

The lack of approved therapies for hepatic fibrosis seriously limits medical management of
patients with chronic liver disease. Since extracellular vesicles (EVs) function as conduits for …