Research methodologies to address clinical unmet needs and challenges in alcohol‐associated liver disease

AK Singal, P Kwo, A Kwong, S Liangpunsakul… - …, 2022 - Wiley Online Library
Alcohol‐associated liver disease (ALD) is emerging worldwide as the leading cause of liver‐
related morbidity, mortality, and indication for liver transplantation. The ALD Special Interest …

[PDF][PDF] MicroRNA‐506 promotes primary biliary cholangitis–like features in cholangiocytes and immune activation

O Erice, P Munoz‐Garrido, J Vaquero… - …, 2018 - Wiley Online Library
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease associated with
autoimmune phenomena targeting intrahepatic bile duct cells (cholangiocytes). Although its …

Adipose-derived mesenchymal stem cell-secreted extracellular vesicles alleviate non-alcoholic fatty liver disease via delivering miR-223-3p

Q Niu, T Wang, Z Wang, F Wang, D Huang, H Sun… - Adipocyte, 2022 - Taylor & Francis
Increasing studies have identified the potential of mesenchymal stem cell-derived
extracellular vesicles (MSC-EVs) in non-alcoholic fatty liver disease (NAFLD) treatment …

[HTML][HTML] Therapeutic application of exosomes in inflammatory diseases

JH Suh, HS Joo, EB Hong, HJ Lee, JM Lee - International journal of …, 2021 - mdpi.com
Immunomodulation is on the cusp of being an important therapy for treating many diseases,
due to the significant role of the immune system in defending the human body. Although the …

Methods for exosome isolation and characterization

M Zhou, SR Weber, Y Zhao, H Chen, JM Sundstrom - Exosomes, 2020 - Elsevier
Extracellular vesicles are released from cells under both physiological and
pathophysiological conditions. Exosomes are a class of extracellular vesicles that originate …

[PDF][PDF] Graft‐infiltrating PD‐L1hi cross‐dressed dendritic cells regulate antidonor T cell responses in mouse liver transplant tolerance

Y Ono, A Perez‐Gutierrez, T Nakao, H Dai… - …, 2018 - Wiley Online Library
Although a key role of cross‐dressing has been established in immunity to viral infection and
more recently in the instigation of transplant rejection, its role in tolerance is unclear. We …

Large-scale proteomic assessment of urinary extracellular vesicles highlights their reliability in reflecting protein changes in the kidney

Q Wu, SB Poulsen, SK Murali, PR Grimm… - Journal of the …, 2021 - journals.lww.com
Background Urinary extracellular vesicles (uEVs) are secreted into urine by cells from the
kidneys and urinary tract. Although changes in uEV proteins are used for quantitative …

[PDF][PDF] Hepatocyte TGF‐β signaling inhibiting WAT Browning to promote NAFLD and obesity is associated with let‐7b‐5p

J Zhao, L Hu, W Gui, L Xiao, W Wang… - Hepatology …, 2022 - Wiley Online Library
Transforming growth factor beta (TGF‐β) signaling in hepatocytes promotes steatosis and
body weight gain. However, processes that TGF‐β signaling in hepatocytes promote …

[HTML][HTML] Extracellular vesicles secreted by Giardia duodenalis regulate host cell innate immunity via TLR2 and NLRP3 inflammasome signaling pathways

P Zhao, L Cao, X Wang, J Dong, N Zhang… - PLoS neglected …, 2021 - journals.plos.org
Giardia duodenalis, also known as G. intestinalis or G. lamblia, is the major cause of
giardiasis leading to diarrheal disease with 280 million people infections annually …

[HTML][HTML] Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: A promising drug Potentilla discolor Bunge

L Ji, Q Li, Y He, X Zhang, Z Zhou, Y Gao, M Fang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive accumulation of
hepatic lipids and metabolic stress-induced liver injury. There are currently no approved …