[PDF][PDF] Sarcopenia in cirrhosis: looking beyond the skeletal muscle loss to see the systemic disease

RA Bhanji, AJ Montano‐Loza, KD Watt - Hepatology, 2019 - Wiley Online Library
Sarcopenia is a common complication of cirrhosis and is defined as a progressive and
generalized loss of skeletal muscle mass, strength, and function. Sarcopenia is associated …

Circulating cell-specific extracellular vesicles as biomarkers for the diagnosis and monitoring of chronic liver diseases

LA Newman, K Muller, A Rowland - Cellular and Molecular Life Sciences, 2022 - Springer
Chronic liver diseases represent a burgeoning health problem affecting billions of people
worldwide. The insufficient performance of current minimally invasive tools is recognised as …

Extracellular vesicles in NAFLD/ALD: from pathobiology to therapy

A Hernández, JP Arab, D Reyes, A Lapitz, H Moshage… - Cells, 2020 - mdpi.com
In recent years, knowledge on the biology and pathobiology of extracellular vesicles (EVs)
has exploded. EVs are submicron membrane-bound structures secreted from different cell …

The rise of the opioid epidemic and hepatitis C–positive organs: A new era in liver transplantation

SA Gonzalez, JF Trotter - Hepatology, 2018 - journals.lww.com
Although a key role of cross‐dressing has been established in immunity to viral infection and
more recently in the instigation of transplant rejection, its role in tolerance is unclear. We …

Milder disease stage in patients with primary biliary cholangitis over a 44‐year period: a changing natural history

CFM Perez, JC Goet, WJ Lammers, A Gulamhusein… - Hepatology, 2018 - journals.lww.com
A salient feature of alcoholic liver disease (ALD) is Kupffer cell (KC) activation and
recruitment of inflammatory monocytes and macrophages (MØs). These key cellular events …

Advances in novel strategies for isolation, characterization, and analysis of CTCs and ctDNA

V Yaghoubi Naei, P Bordhan… - Therapeutic …, 2023 - journals.sagepub.com
Over the past decade, the detection and analysis of liquid biopsy biomarkers such as
circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) have advanced …

Intercellular communication between hepatic cells in liver diseases

K Sato, L Kennedy, S Liangpunsakul… - International journal of …, 2019 - mdpi.com
Liver diseases are perpetuated by the orchestration of hepatocytes and other hepatic non-
parenchymal cells. These cells communicate and regulate with each other by secreting …

Cargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis

J Kim, SK Lee, SY Jeong, HJ Cho, J Park… - Journal of …, 2021 - Springer
Abstract Background Extracellular vesicles (EVs) are recognized as novel cell-free
therapeutics. Non-alcoholic steatohepatitis (NASH) remains a critical health problem …

Alcohol Promotes Exosome Biogenesis and Release via Modulating Rabs and miR-192 Expression in Human Hepatocytes

S Bala, M Babuta, D Catalano, A Saiju… - Frontiers in Cell and …, 2022 - frontiersin.org
Exosomes are membrane vesicles released by various cell types into the extracellular space
under different conditions including alcohol exposure. Exosomes are involved in …

Advanced Nanoencapsulation-Enabled Ultrasensitive Analysis: Unraveling Tumor Extracellular Vesicle Subpopulations for Differential Diagnosis of Hepatocellular …

X Li, Y Liu, Y Fan, G Tian, B Shen, S Zhang, X Fu… - ACS …, 2024 - ACS Publications
Tumor-derived extracellular vesicles (tEVs) hold immense promise as potential biomarkers
for the precise diagnosis of hepatocellular carcinoma (HCC). However, their clinical …