The hallmark of NAFLD is steatosis of unknown etiology. We tested the effect of a high-
protein (HP) 2 diet on diet-induced steatosis in male C57BL/6 mice with and without pre …

Introduction: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative
disease. We sought to determine whether peroxisome proliferator–activated receptor γ …

Aims Overexpression of either member of the miR-199 family, miR-199a-5p, or miR-199b-5p
(hereinafter referred to as miR-199a or miR-199b) promotes pathological cardiac …

Objective Human TNKS, encoding tankyrase 1 (TNKS1), localizes to a susceptibility locus
for obesity and type 2 diabetes mellitus (T2DM). Here, we addressed the therapeutic …

Background and aim Metabolic syndromes are prevalent worldwide and result in various
complications including obesity, cardiovascular disease and type II diabetes. Betulinic acid …

Skeletal muscle is an organ involved in whole body movement and energy metabolism with
the ability to dynamically adapt to different states of (dis-) use. At a molecular level, the …

Objective β-secretase/β-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is
a key enzyme involved in Alzheimer's disease that has recently been implicated in insulin …

Exercise triggers a pleiotropic response in skeletal muscle, which results in a profound
remodeling of this tissue. Physical activity–dependent muscle fiber plasticity is regulated by …

During pathological hypertrophy, peroxisome proliferator-activated receptor coactivator 1α
(PGC-1α) is repressed in concert with reduced mitochondrial oxidative capacity and fatty …

The peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) interacts with
various transcription factors involved in energy metabolism and in the regulation of …