The peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) interacts with
various transcription factors involved in energy metabolism and in the regulation of …

We investigated the effects of PGC‐1α (peroxisome proliferator‐activated receptor γ
coactivator‐1α) overexpression on the oxidative capacity of human skeletal muscle cells ex …

Sleep loss has emerged as a risk factor comparable to that of physical inactivity for the
development of insulin resistance, impaired glucose tolerance and type 2 diabetes mellitus …

Brain-derived neurotropic factor (BDNF) mediates many aspects of neuronal function, and
plays a chief role in the central regulation of energy balance. In the periphery, it is expressed …

Oxidative stress has been associated with insulin resistance and type 2 diabetes. However,
it is not clear whether oxidative damage is a cause or a consequence of the metabolic …

Background The hypertensive, pro-inflammatory, obese state is strongly coupled to
peripheral and hepatic insulin resistance (in composite termed metabolic syndrome [MS]) …

The increasing prevalence of obesity and its comorbidities represents a major threat to
human health globally. Pharmacological treatments exist to achieve weight loss, but the …

Loss of parkin E3 ligase activity as a result of parkin gene mutation in rare familial forms of
Parkinson's disease (PD) has been shown to be detrimental to mitochondrial function and to …

10-Hydroxy-2-decenoic acid (10H2DA) is a fatty acid found in royal jelly (RJ). In healthy
mice, it activates 5'-AMP-activated protein kinase (AMPK) and increases glucose transporter …

Mitochondrial dysfunction plays a role in the pathogenesis of a wide range of diseases that
involve disordered cellular fuel metabolism and survival/death pathways, including …