Advances in receptor‐mediated, tumor‐targeted drug delivery
Receptor‐mediated drug delivery presents an opportunity to enhance therapeutic efficiency
by accumulating drug within the tissue of interest and reducing undesired, off‐target effects …
by accumulating drug within the tissue of interest and reducing undesired, off‐target effects …
[HTML][HTML] The role of the androgen receptor in prostate development and benign prostatic hyperplasia: A review
RE Vickman, OE Franco, DC Moline… - Asian journal of …, 2020 - Elsevier
Benign prostatic hyperplasia (BPH) is a benign enlargement of the prostate in which
incidence increases linearly with age, beginning at about 50 years old. BPH is a significant …
incidence increases linearly with age, beginning at about 50 years old. BPH is a significant …
[HTML][HTML] Functional analysis of androgen receptor mutations that confer anti-androgen resistance identified in circulating cell-free DNA from prostate cancer patients
Background The androgen receptor (AR) is a pivotal drug target for the treatment of prostate
cancer, including its lethal castration-resistant (CRPC) form. All current non-steroidal AR …
cancer, including its lethal castration-resistant (CRPC) form. All current non-steroidal AR …
[HTML][HTML] The androgen receptor in prostate cancer: Effect of structure, ligands and spliced variants on therapy
EA Messner, TM Steele, MM Tsamouri, N Hejazi… - Biomedicines, 2020 - mdpi.com
The androgen receptor (AR) plays a predominant role in prostate cancer (PCa) pathology. It
consists of an N-terminal domain (NTD), a DNA-binding domain (DBD), a hinge region (HR) …
consists of an N-terminal domain (NTD), a DNA-binding domain (DBD), a hinge region (HR) …
[HTML][HTML] Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancer
K Dalal, M Roshan-Moniri, A Sharma, H Li… - Journal of biological …, 2014 - ASBMB
The androgen receptor (AR) is a transcription factor that has a pivotal role in the occurrence
and progression of prostate cancer. The AR is activated by androgens that bind to its ligand …
and progression of prostate cancer. The AR is activated by androgens that bind to its ligand …
A magic drug target: Androgen receptor
D Li, W Zhou, J Pang, Q Tang, B Zhong… - Medicinal research …, 2019 - Wiley Online Library
Androgen receptor (AR) is closely associated with a group of hormone‐related diseases
including the cancers of prostate, breast, ovary, pancreas, etc and anabolic deficiencies …
including the cancers of prostate, breast, ovary, pancreas, etc and anabolic deficiencies …
Bioactive natural products for chemoprevention and treatment of castration-resistant prostate cancer
G Kallifatidis, JJ Hoy, BL Lokeshwar - Seminars in cancer biology, 2016 - Elsevier
Prostate cancer (PCa), a hormonally-driven cancer, ranks first in incidence and second in
cancer related mortality in men in most Western industrialized countries. Androgen and …
cancer related mortality in men in most Western industrialized countries. Androgen and …
[HTML][HTML] Androgen signaling in uterine diseases: new insights and new targets
M Lv, J Yu, Y Huang, J Ma, J Xiang, Y Wang, L Li… - Biomolecules, 2022 - mdpi.com
Common uterine diseases include endometriosis, uterine fibroids, endometrial polyps,
endometrial hyperplasia, endometrial cancer, and endometrial dysfunction causing infertility …
endometrial hyperplasia, endometrial cancer, and endometrial dysfunction causing infertility …
Selectively targeting the dimerization interface of human androgen receptor with small-molecules to treat castration-resistant prostate cancer
K Dalal, F Ban, H Li, H Morin, M Roshan-Moniri… - Cancer letters, 2018 - Elsevier
Prostate cancer (PCa) is a leading cause of death for men in North America. The androgen
receptor (AR)-a hormone inducible transcription factor-drives expression of tumor promoting …
receptor (AR)-a hormone inducible transcription factor-drives expression of tumor promoting …
Molecules targeting the androgen receptor (AR) signaling axis beyond the AR‐Ligand binding domain
NGRD Elshan, MB Rettig… - Medicinal research reviews, 2019 - Wiley Online Library
Prostate cancer (PCa) is the second most common cause of cancer‐related mortality in men
in the United States. The androgen receptor (AR) and the physiological pathways it …
in the United States. The androgen receptor (AR) and the physiological pathways it …