Cellular senescence is a state of terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory phenotype. In the brain, senescent cells …

Brain aging is a recognized risk factor for neurodegenerative diseases like Alzheimer's
disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS, Lou Gehrig's …

Background Inflammaging represents an accepted concept where the immune system shifts
to a low-grade chronic pro-inflammatory state without overt infection upon aging. In the CNS …

Neuroinflammatory diseases remain a therapeutic challenge, notably when progressing
towards neurodegeneration. In this context, multiple sclerosis represents a central nervous …

During recent decades, model organisms such as Drosophila melanogaster have made it
possible to study the effects of different environmental oxygen conditions on lifespan and …

Abstract c-Jun activation domain binding protein-1 (JAB1) is a multifunctional regulator that
plays vital roles in diverse cellular processes. It regulates AP-1 transcriptional activity and …

Abstract The constitutive photomorphogenesis 9 (COP9) signalosome (CSN) is a
deNEDDylase controlling ubiquitination activity of cullin-RING-E3 ligases (CRLs) and thus …

Jab1/COPS5 is associated with the progression of some cancers, however, its role in most
cancers is still unclear. This study systematically explored the action and clinical application …

This study addresses a joint nuclear magnetic resonance (NMR) and electron paramagnetic
resonance (EPR) spectroscopy approach to provide a platform for dynamic assessment of …

Experimental autoimmune encephalomyelitis (EAE) is a demyelinating disease affecting the
central nervous system (CNS) in animals that parallels several clinical and molecular traits …