In the past several decades, we have gained an increasing understanding of the course of
depression. Previously viewed as an acute and self-limiting illness, it is now clear that, for …

Kraepelin had a modern vision of affective illness. He hypothesized that affective
recurrences arose from enduring dispositions of depressive, cyclothymic, irritable, or …

Background This report presents the results of confirmatory factor analyses of patterns of
comorbidity among 10 common mental disorders in the National Comorbidity Survey, a …

This tenth anniversary review/update of fluoxetine concentrates on the past 5 years of its
clinical application. The mechanism of action of fluoxetine; its metabolism; its efficacy in …

In a multicentre, double blind, parallel group study 281 patients with DSM III-R diagnosis of
dysthymia or a single episode of major depression in partial remission were randomised to 3 …

Although dysthymia, a chronic, low-grade form of depression, has a morbidity rate as high as
that of major depression, and increases the risk for major depressive disorder, limited …

Major depression and dysthymia (chronic, low grade depression) were associated with an
increase in the number of CD16/56 (natural killer; NK) cells in blood, whereas other …

1. Both major depression and dysthymia (chronic, low grade depression) were associated
with increased reports of minor stressors (daily hassles), and feelings of loneliness, reduced …

We studied the effects of a fixed dose of fluoxetine (20 mg) or cognitive psycho‐therapy in a
16 week trial of patients with dysthymic disorder. More patients assigned to fluoxetine …

The relationship between primary dysthymia (chronic, low grade depression) and indices of
major and minor life stresses, uplifts and coping styles was examined. Additionally …