Gene therapy holds great promise for treating a multitude of inherited and acquired diseases
by delivering functional genes, comprising DNA or RNA, into targeted cells or tissues to elicit …

Short interfering RNAs (siRNA) are a powerful class of genetic medicines whose clinical
translation can be hindered by their suboptimal delivery properties in vivo. Here, we provide …

Synthetic polymers are versatile and widely used materials. Similar to small organic
molecules, a large chemical space of such materials is hypothetically accessible …

In the past decade, there has been a shift in research, clinical development, and commercial
activity to exploit the many physiological roles of RNA for use in medicine. With the rapid …

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …

Bioresponsive polymers have been widely used in drug delivery because of their
degradability. For example, poly (disulfide) s with repeating disulfide bonds in the main …

Lipid nanoparticles (LNPs) are currently the most promising clinical nucleic acids drug
delivery vehicles. LNPs prevent the degradation of cargo nucleic acids during blood …

The use of biodegradable polymeric nanoparticles (NPs) for controlled drug delivery has
shown significant therapeutic potential. Concurrently, targeted delivery technologies are …

The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐
associated protein 9 (Cas9) system offers great opportunities for the treatment of numerous …

Nucleic acid vaccines, especially messenger RNA (mRNA) vaccines, display unique
benefits in the current COVID-19 pandemic. The application of polymeric materials as …