[HTML][HTML] Autophagy and autophagy signaling in Epilepsy: Possible role of autophagy activator

NH Ali, HM Al-Kuraishy, AI Al-Gareeb, SA Alnaaim… - Molecular …, 2023 - Springer
Autophagy is an explicit cellular process to deliver dissimilar cytoplasmic misfolded proteins,
lipids and damaged organelles to the lysosomes for degradation and elimination. The …

[HTML][HTML] The possible role of brain-derived neurotrophic factor in epilepsy

R AlRuwaili, HM Al-Kuraishy, AI Al-Gareeb… - Neurochemical …, 2024 - Springer
Epilepsy is a neurological disease characterized by repeated seizures. Despite of that the
brain-derived neurotrophic factor (BDNF) is implicated in the pathogenesis of …

[HTML][HTML] Antiseizure medications in Alzheimer's disease from preclinical to clinical evidence

F Bosco, L Guarnieri, V Rania, E Palma… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) and epilepsy are common neurological disorders in the elderly. A
bi-directional link between these neurological diseases has been reported, with patients …

[HTML][HTML] Mechanisms involved in epileptogenesis in Alzheimer's disease and their therapeutic implications

M Altuna, G Olmedo-Saura, M Carmona-Iragui… - International journal of …, 2022 - mdpi.com
Epilepsy and Alzheimer's disease (AD) incidence increases with age. There are reciprocal
relationships between epilepsy and AD. Epilepsy is a risk factor for AD and, in turn, AD is an …

Epileptic prodromal Alzheimer's disease treated with Antiseizure medications: medium-term outcome of seizures and cognition

G Hautecloque-Raysz, F Sellal… - Journal of …, 2023 - content.iospress.com
Background: The medium term outcome (over more than one year) of epileptic prodromal
AD (epAD) patients treated with antiseizure medications (ASMs) is unknown in terms of …

[HTML][HTML] Alzheimer's disease and epilepsy: the top 100 cited papers

GF Zhang, WX Gong, ZYR Xu, Y Guo - Frontiers in Aging …, 2022 - frontiersin.org
Background Alzheimer's disease (AD) is one of the common neurodegenerative diseases,
which often coexists with epilepsy. It is very significant to study the treatment options and the …

[HTML][HTML] Sleep: The Tip of the Iceberg in the Bidirectional Link Between Alzheimer's Disease and Epilepsy

A B. Szabo, B Cretin, F Gérard, J Curot… - Frontiers in …, 2022 - frontiersin.org
The observation that a pathophysiological link might exist between Alzheimer's disease (AD)
and epilepsy dates back to the identification of the first cases of the pathology itself and is …

Safe and Interpretable Estimation of Optimal Treatment Regimes

H Parikh, QM Lanners, Z Akras… - International …, 2024 - proceedings.mlr.press
Recent advancements in statistical and reinforcement learning methods have contributed to
superior patient care strategies. However, these methods face substantial challenges in high …

Recommendations for preclinical testing of treatments against Alzheimer's disease-related epileptiform spikes in transgenic rodent models

N Jin, C Babiloni, WH Drinkenburg… - Journal of …, 2022 - content.iospress.com
Recent evidence suggests that about 30% of patients with mild to moderate Alzheimer's
disease (AD) without a known diagnosis of epilepsy may display epileptiform spikes during …

Treatment of epilepsy in the setting of cognitive decline in older adults

J Mayo, S Panahi, A Roghani, AC Van Cott… - … Treatment Options in …, 2022 - Springer
Abstract Purpose of Review Discuss the state of the literature for the treatment of comorbid
epilepsy and cognitive dysfunction, specifically focusing on the older adult. Recent Findings …