Remodelling is a response of the myocardium and vasculature to a range of potentially
noxious haemodynamic, metabolic, and inflammatory stimuli. Remodelling is initially …

The pathophysiology of heart failure (HF) is characterized by hemodynamic abnormalities
that result in neurohormonal activation and autonomic imbalance with increase in …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Adrenergic receptors (AR) are G-protein-coupled receptors (GPCRs) that have a crucial role
in cardiac physiology in health and disease. Alpha1-ARs signal through G α q, and signaling …

G protein–coupled receptors (GPCRs) continue to be important discovery targets for the
treatment of type 2 diabetes mellitus (T2DM). Many GPCRs are directly involved in the …

Abstract α1-adrenergic receptors (α1-ARs) play critical roles in the cardiovascular and
nervous systems where they regulate blood pressure, cognition, and metabolism. However …

Background—Activation of the renin-angiotensin and sympathetic nervous systems may
alter the cardiac energy substrate preference, thereby contributing to the progression of …

Voltage-gated potassium (Kv) channels contain voltage-sensing (VSD) and pore-gate (PGD)
structural domains. During voltage-dependent gating, conformational changes in the two …

G protein coupled receptors (GPCRs) were first characterized as signal transducers that
elicit downstream effects through modulation of guanine (G) nucleotide-binding proteins …

α1‐Adrenoceptors are seven transmembrane domain GPCRs involved in numerous
physiological functions controlled by the endogenous catecholamines, noradrenaline and …