Intrinsic, widefield optical imaging of hemodynamics in rodent models of Alzheimer's disease and neurological injury

C Crouzet, T Phan, RH Wilson, TJ Shin… - …, 2023 - spiedigitallibrary.org
The complex cerebrovascular network is critical to controlling local cerebral blood flow
(CBF) and maintaining brain homeostasis. Alzheimer's disease (AD) and neurological injury …

From 1901 to 2022, how far are we from truly understanding the pathogenesis of age-related dementia?

X Fang, J Zhang, RJ Roman, F Fan - Geroscience, 2022 - Springer
From the first described AD case in 1901 to the current year 2022, understanding the
pathogenesis of Alzheimer's disease (AD) and dementia has undergone a long and tortuous …

Preserved blood-brain barrier and neurovascular coupling in female 5xFAD model of Alzheimer's disease

O Zhukov, C He, R Soylu-Kucharz, C Cai… - Frontiers in Aging …, 2023 - frontiersin.org
Dysfunction of the cerebral vasculature is considered one of the key components of
Alzheimer's disease (AD), but the mechanisms affecting individual brain vessels are poorly …

Optical Devices for the Diagnosis and Management of Spinal Cord Injuries: A Review

S Sharma, N Kalyani, T Dutta, JS Velázquez-González… - Biosensors, 2024 - mdpi.com
Throughout the central nervous system, the spinal cord plays a very important role, namely,
transmitting sensory and motor information inwardly so that it can be processed by the brain …

Cortical microvascular blood flow velocity mapping by combining dynamic light scattering optical coherence tomography and two-photon microscopy

Q Pian, M Alfadhel, J Tang, GV Lee, B Li… - Journal of …, 2023 - spiedigitallibrary.org
Significance The accurate large-scale mapping of cerebral microvascular blood flow velocity
is crucial for a better understanding of cerebral blood flow (CBF) regulation. Although optical …

[PDF][PDF] Revisiting the effects of exercise on cerebral neurovascular functions in rats using multimodal assessment techniques

S Yen, HY Wu, Y Wang, CM Huang, CW Wu, JH Chen… - Iscience, 2023 - cell.com
Physical activity in the form of aerobic exercise has many beneficial effects on brain function.
Here, we aim to revisit the effects of exercise on brain morphology and neurovascular …

Extracellular Alterations in pH and K+ Modify the Murine Brain Endothelial Cell Total and Phospho-Proteome

JR Wahl, A Vivek, SM Palomino, M Almuslim… - Pharmaceutics, 2022 - mdpi.com
Pathologies of the blood–brain barrier (BBB) have been linked to a multitude of central
nervous system (CNS) disorders whose pathology is poorly understood. Cortical spreading …

[HTML][HTML] Behavioral and neural activity-dependent recanalization of plugged capillaries in the brain of adult and aged mice

P Reeson, B Schager, M Van Sprengel… - Frontiers in Cellular …, 2022 - frontiersin.org
The capillaries of the brain, owing to their small diameter and low perfusion pressure, are
vulnerable to interruptions in blood flow. These tiny occlusions can have outsized …

Low-invasive neural recording in mouse models with diabetes via an ultrasmall needle-electrode

R Sanda, K Yamashita, H Sawahata… - Biosensors and …, 2023 - Elsevier
Diabetes is known to cause a variety of complications, having a high correlation with
Alzheimer's disease. Electrophysiological recording using a microscale needle electrode is …

Depression of dynamic cerebral autoregulation during neural activation: the role of responders and non-responders

K Ladthavorlaphatt, FBS Surti… - Journal of Cerebral …, 2024 - journals.sagepub.com
Neurovascular coupling (NVC) interaction with dynamic cerebral autoregulation (dCA)
remains unclear. We investigated the effect of task complexity and duration on the …